Tragically common among children in sub-Saharan Africa, cerebral malaria is characterized by rapid progression to coma and death. In this study, we used a model of cerebral malaria appearing in C57BL/6 WT mice after infection with the rodent malaria parasite Plasmodium berghei ANKA. Expression and cellular localization of the brain water channel aquaporin-4 (AQP4) was investigated during the ne...

Cerebral malaria is one of the most serious manifestations of severe malaria in adults. The exact pathophysiology of the disease, however, is still elusive. The ocular fundus findings are supposed to reflect the pathological changes taking place in the cerebral tissue. In about 15% patients of cerebral malaria, retinal hemorrhages are seen1. They are multiple and bilateral, and the most common ...

Lymphocytes are implicated in immunity and pathogenesis of severe malaria. Since lymphocyte subsets vary with age, assessment of their contribution to different etiologies can be difficult. We immunophenotyped peripheral blood from Malawian children presenting with cerebral malaria, severe malarial anemia, and uncomplicated malaria (n = 113) and healthy aparasitemic children (n = 42) in Blantyr...

BACKGROUND Human immunodeficiency virus (HIV)-1 infection increases the burden of malaria by increasing susceptibility to infection and decreasing the response to malarial treatment. HIV-1 has also been found to suppress the immune system and predispose to severe forms of malaria in adults. There is still a paucity of data on the association between HIV-1 infection and cerebral malaria in child...

OBJECTIVE We hypothesize that upper gastrointestinal symptoms in cerebral malaria are due to gastric motor dysfunction. But gastric motility studies in cerebral malaria are scarce. METHODS We determined gastric emptying half-time (GET½) of liquid meals quantitatively by radio isotope scintigraphy in 25 patients of cerebral malaria and 10 healthy controls. RESULTS GET½ was prolonged (46.5 ± ...

Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium falciparum. The pathogenic mechanisms leading to cerebral malaria are still poorly defined as studies have been hampered by limited accessibility to human tissues. Nevertheless, histopathology of post-mortem human tissues and mouse models of cerebral malaria have indicated involvement of the blood-brain bar...

We conducted this study to determine the prognostic significance of the platelet count in children with cerebral malaria. We studied children with cerebral malaria admitted to the pediatric research ward at Queen Elizabeth Central Hospital, Malawi. We analyzed 1,811 children with cerebral malaria and compared them with 521 children with bacterial meningitis. There was a significant difference i...

Revised results section Results: HIV-1 infection was present in 9% of children with cerebral malaria compared to 2.3% in uncomplicated malaria (age-adjusted odds ratio (aOR) 5.94 (95% confidence interval (CI) 1.23-28.72, p=0.012); and 2.5% in children with no malaria (aOR 3.85 (95% CI0.98-15.07, p= 0.037). The age-adjusted odds of being HIV-positive among children with cerebral malaria compared...

Background Malaria remains one of the deadliest diseases in tropic. Its severe form represents a major public health concern sub-Saharan Africa. The study aimed to describe and analyze clinical features outcomes malaria children from Libreville. Methods Medical records (March 2018- December 2019) emergency ward “Mother Child University Hospital” were analyzed. Children hospitalized for who met ...