In emergency and critical care medicine, lung ischemia-reperfusion injury is a prevalent disorder, which has significant morbidity mortality. However, there still lack of effective means to block the injury. Established model mice; histological analysis scoring were helpful assess pathological in tissue; using an enzymelinked immunosorbent assay kit, expressed interleukin-6 interleukin-1 bronch...

Ischemia-reperfusion injury, a common complication during liver surgery where steatotic livers are more prone to the injury, may become more prevalent in the growing obese population. This study characterizes liver morphology toward understanding changes in subcellular function in steatotic livers exposed to ischemiareperfusion injury through quantitative description of fluorescein distribution...

pediatric neurological disorders including muscular dystrophy, cerebral palsy, and spinal cord injury are defined as a heterogenous group of diseases, of which some are known to be genetic. the two significant features represented for stem cells, leading to distinguish them from other cell types are addressed as below: they can renew themselves besides the ability to differentiate into cells wi...

Purpose: To study the effect of dexmedetomidine (Dex) on myocardial ischemia-reperfusion injury (MIRI), and associated mechanism action.Methods: Sixty Sprague-Dawley (SD) rats were assigned to sham, (I/R), Dex, MD groups (methyllycaconitine prior injection with Dex), 15 in each group. Pathological changes tissues determined all groups. Protein expression levels HMGB1, TLR4, NF-κB myeloid differ...

SUDDEN CARDIAC ARREST IS THE most common lethal consequence of cardiovascular disease. Even if return of spontaneous circulation (ROSC) from cardiac arrest is achieved, approximately 60% of patients will not survive to hospital discharge. The high mortality is attributed to the postcardiac arrest syndrome, which involves global ischemiareperfusion injury, myocardial stunning, and anoxic brain i...

Molnar, M. 2015. Hyperglycemia in Experimental Cerebral Ischemia. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1089. 86 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9216-8. Cerebral ischemia is a life-threatening condition associated with a substantial morbidity and mortality. Hyperglycemia, a common coexisting phenomenon in both stroke a...

SEE PAGE 47 A MP-activated protein kinase (AMPK) is a molecular energy sensor that is essential to the stress response in the heart (1). AMPK is activated during energy imbalance, when the ADPor AMP-toATP ratio increases. Because few proteins have adenine nucleotide binding domains, the activation of a protein kinase, which phosphorylates numerous downstream proteins, amplifies the energy stres...