Central composite design of Response Surface Methodology (RSM) was used to study the effect of sodium chloride; NaCl (0.5-1%) and salt replacer potassium chloride KCl (0.5-1%) in combination with whey protein concentrate (0.5-1.5%) and black gram flour (2-4%) on the overall acceptability, saltiness and instrumental hardness of low salt restructured chicken nuggets. Reduction of NaCl content to ...

The preformulation of insoluble drugs, sulfadiazine and aluminium hydroxyde, were studied in order to achieve a suspension with desirable requirements. The objective of the formulator is to avoid the irreversible aggregation called “caking”, and to obtain a suspension with an airy, large volume sediment easily redispersible and with suitable rheological properties. An experimental design useful...

The process parameters, temperature, pH and substrate concentration, were optimized for the production of gentamicin using Micromonouspora echinospora. Experiments were carried out according to central composite design in response surface method. The optimum conditions for the maximum production of gentamicin were found to be: temperature – 31.7C, pH – 6.8 and substrate concentration – 3%. At t...

Trichoderma species are widely used for the commercial production of cellulolytic enzymes. In the present investigation, medium components were optimized using a central composite design and response surface methodology to produce endoglucanase (EG) from Trichoderma harzianum KUC1716. From the various medium components tested, cellulose, soy peptone, and thiamine HCl were selected as the optima...

Cutting tests were conducted to medium carbon steel using HSS tools with cutting fluid. The experimental design used was based on response surface methodology (RSM) using a central composite design. Chips were collected at different machining conditions and thickness and microhardness measurements taken and analyzed using “DESIGN EXPERT 7” experimental design software. Mathematical models of th...

The process parameters, temperature, pH and substrate concentration, were optimized for the production of gentamicin using Micromonouspora echinospora. Experiments were carried out according to central composite design in response surface method. The optimum conditions for the maximum production of gentamicin were found to be: temperature – 31.7C, pH – 6.8 and substrate concentration – 3%. At t...

In this study, the effects of machining parameters on specific energy during surface grinding of 6061Al-SiC35P composites are investigated. Vol% of SiC, feed and depth of cut were chosen as process variables. The power needed for the calculation of the specific energy is measured from the two watt meter method. Experiments are conducted using standard RSM design called Central composite design ...

Pectin from passion fruit peels was extracted using citric acid extraction. The effects of citric acid concentration from 0.05 to 0.21 % (wt/wt), extraction time from 30 to 120 minutes and extraction temperatures from 35 to 85 ̊C on pectin yield and the degree of esterification (DE) were investigated. Using the central composite design (CCD), the optimized pectin yield was 6.44 % and degree of ...

ABSTRACT: Aqueous enzymatic extraction of oil from pistacia khinjuk was performed using cellulase. The central composite design was used to optimize the parameters that are significant to the process. The influence of three regressors on the percentage of oil recovery from seed was evaluated using second-order polynomial multiple regression model. Analysis of variance showed a high coefficient ...

there have been many productive methods developed so far for optimization of multiple response surface (mrs) problems. this paper tends to review the most seminal approaches in mrs and discuss the strength and weakness of each of the approaches through existing aspects in mrs. a numerical example is included to compare results by different methods. finally some of the prominent areas for future...