Article history: Received on: 05/10/2015 Revised on: 23/10/2015 Accepted on: 08/11/2015 Available online: 27/12/2015 This work, for the first time reports the optimization of recombinant human antithrombin (rhAT) production in Saccharomyces cerevisiae BY4741 using statistical experimental designs. Most applications of design of experiments (DoE) have concerned optimization of the composition of...

An aqueous solution of boric acid, as an efficient and green catalytic system, was efficiently utilized four-component cascade reaction of aryl aldehydes, dimedone, β-ketoesters and ammonium acetate to give hexahydroquinolines. By the reaction of boric acid with water, H+ was generated and efficiently catalyzed the reaction under mild and green condition. Also, optimization of the reaction cond...

Olive products, such as oils, olives and leaves infusions, have been used in the past to treat many health problems. This study aims to develop a methodology for maximizing the efficiency of extraction of polyphenols from olive leaves. For this purpose, two experimental design approaches (a central composite design (CCD) and a mixture design) have been used. The optimal extraction parameters ob...

the aim of this research was to optimize bioremediation of seawater samples spiked with 1000 mg/l crude oil for removal of n-alkanes (c12h26 to c34h70). bioaugmentation experiments were performed at laboratory scale: each bioreactor contained 250 ml dispersed crude-oil-contaminated seawater, indigenous acclimatized microorganism and nitrogen and phosphorus at concentrations based on central com...

the aim of this investigation was to prepare, characterize and optimize the aceclofenac proniosomes using central composite design and carry out stability studies. three independent variables selected were molar ratio of drug to lipid (x1), surfactant loading (x2) and volume of hydration (x3). based on central composite design, 16 batches of proniosomes were prepared by slurry method and evalua...

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The objective of the research is to study and compare response surface designs: Central composite designs (CCD), BoxBehnken designs (BBD), Small composite designs (SCD), Hybrid designs, and Uniform shell designs (USD) over sets of reduced models when the design is in a spherical region for 3 and 4 design variables. The two optimality criteria ( D and G ) are considered which larger values imply...

In this work, perlite was used as a low-cost source of Si and Al in the synthesis of sodalite zeolite using hydrothermal synthesis method. Cu2O nanoparticles were coated on a bed of sodalite zeolite and used as an adsorbent for removal of diazinon from aqueous solutions. To analyze the process, a significant variable .i.e. removal efficiency (%) of diazinon and three dependent parameters as the...

isoniazid (inh) was studied with regard to its electrochemical treatment on a strongly alkaline solution of a poly (3,4-ethylenedioxythiophene)-modified gold electrode, using both cyclic voltammetry and controlled potential techniques. this composite electrode exhibited 4-fold higher oxidation of inh, in accordance with peak densities, than the bare gold electrode. it was used the central compo...