We report the successful control of bleeding in two patients who underwent post-cardiotomy extracorporeal circulatory support (ECMO) and then developed life-threatening bleeding due to severe coagulopathy. After the failure of conventional techniques, bleeding control was achieved using Celox Gauze (MedTrade Products Ltd, Cheshire, UK) packed on the sternal edges and pericardial cavity.

The effectiveness of three types of hemostatic dressings, QuikClot Gauze, ChitoGauze PRO and Celox Gauze, was evaluated in nine pigs. The results indicated a strong influence of all examined dressings on porcine femoral muscle tissue evaluated 24 hours after direct contact. A histopathological analysis revealed pathological changes in muscle tissue specimens collected from all the animals.

Celox (MedTrade Products Ltd, Cheshire, UK) is a proprietary preparation of chitosan, indicated for moderate to severe hemorrhage and currently used for hemostasis in the emergency and military settings. We describe its lifesaving use in 2 patients undergoing cardiothoracic surgery in which conventional techniques had failed.

Background: Common measures to stop bleeding can run the risk of clotting and thrombosis due to prolonged application of pressure. Topical homeostatic agents have an important role in decreasing time to hemostasis and consequently prevention of the complications.   Aim: the aim of this study was to compare Celox powder and conventional bandage on time to hemostasis in the vascular access site i...

Uncontrolled hemorrhage has been considered as one of the most important factors for causing death on the battlefront. If given timely and efficient hemostatic medicines in pre-hospital setting, patients will obtain more time and chance to wait for medical treatment so as to save their lives. However, there is not a certain answer about which kind of hemostatic drugs can achieve efficacious eff...

BACKGROUND The use of mineral (clay) or biologic (chitosan) materials has improved the efficacy of dressings used in the bleeding control of noncompressible areas. A series of novel manufactured products already evaluated in a vascular transection model was further compared in a severe vascular puncture injury model. METHODS Ten hemostatic dressings were tested in anesthetized Yorkshire swine...

OBJECTIVES Uncontrolled hemorrhage remains a leading cause of traumatic death. Several topical adjunct agents have been shown to be effective in controlling hemorrhage, and two, chitosan wafer dressing (HemCon [HC]) and zeolite powder dressing (QuikClot [QC]), are being utilized regularly on the battlefield. However, recent literature reviews have concluded that no ideal topical agent exists. T...

Objectives: Uncontrolled hemorrhage remains a leading cause of traumatic death. Several topicaladjunct agents have been shown to be effective in controlling hemorrhage, and two, chitosan waferdressing (HemCon [HC]) and zeolite powder dressing (QuikClot [QC]), are being utilized regularly on thebattlefield. However, recent literature reviews have concluded that no ideal topical agent...

Hemorrhage remains the leading cause of combat death and a major cause of death from potentially survivable injuries. Great strides have been made in controlling extremity hemorrhage with tourniquets, but not all injuries are amenable to tourniquet application. Topical hemostatic agents and dressings have also contributed to success in controlling extremity and compressible junctional hemorrhag...