Studies in athletes have shown that carnitine supplementation may foster exercise performance. As reported in the majority of studies, an increase in maximal oxygen consumption and a lowering of the respiratory quotient indicate that dietary carnitine has the potential to stimulate lipid metabolism. Treatment with L-carnitine also has been shown to induce a significant postexercise decrease in ...

Mitochondria play important roles in human physiological processes, and therefore, their dysfunction can lead to a constellation of metabolic and nonmetabolic abnormalities such as a defect in mitochondrial gene expression, imbalance in fuel and energy homeostasis, impairment in oxidative phosphorylation, enhancement of insulin resistance, and abnormalities in fatty acid metabolism. As a conseq...

We have previously demonstrated that carnitine deficiency aggravated paracetamol-induced hepatopathy and carboplatin-induced nephropathy. As a continuum, we have addressed in the current study as to whether carboplatininduced myelosuppression would be exacerbated by carnitine deficiency. Challenging male Wistar rats with a single dose of carboplatin (35 mg/kg, IP) induced bone marrow suppressio...

Jacyno E., A. Kołodziej, M. Kamyczek, M. Kawęcka, K. Dziadek, A. Pietruszka: Effect of L-Carnitine Supplementation on Boar Semen Quality. Acta Vet Brno 2007, 76: 595-600. The effect of addition of L-carnitine on boar semen quality was studied in 5 Pietrain boars at age 1.5 2.0 years. The boars received 500 mg of L-carnitine per day for 5 weeks. During this period, their ejaculates were collecte...

background: l-carnitine has been demonstrated to confer cardiac protection against ischemia reperfusion injury in animals. this study evaluates the effects of l-carnitine administration on cardiac biomarkers after coronary artery bypass graft (cabg) surgery. methods: one hundred thirty-four patients undergoing elective cabg surgery, without a history of myocardial ischemia or previous l-carniti...

Diabetes mellitus is a widespread metabolic disease characterized by hyperglycemia and associated with severe complications, including cardiovascular disease and dyslipidemia. The cardiovascular risk is considerably increased in diabetic patients, and novel cardioprotective strategies are sought that could target both diabetic and cardiovascular outcomes. L-carnitine is a conditionally essentia...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background : previous reports have suggested acute phase proteins, such as albumin, to alter in hemodialysis (hd) patients. intravenous l-carnitine supplementation is expected to improve the level of plasma albumin in hd patients. this study was performed to evaluate the effects of oral l-carnitine supplementation on hemog...

Acylcarnitines, important lipid biomarkers reflective of acyl-CoA status, are metabolites that possess bioactive and inflammatory properties. This study examined the potential for long-chain acylcarnitines to activate cellular inflammatory, stress, and death pathways in a skeletal muscle model. Differentiated C2C12 myotubes treated with l-C14, C16, C18, and C18:1 carnitine displayed dose-depend...

abstract background: sperm cells extracted from testes (tese) have poor chromatin quality and motility. various substances are used in the laboratory to increase sperm motility and improve the art outcomes; however, there are few research which considered improving both sperm motility and chromatin quality. objective: the aim of this investigation was to evaluate the improvement of the testicul...

CARNITINE IS A CRITICAL COFACTOR in the metabolism of lipids and therefore in the production of cellular energy. L-Carnitine, the active form, plays an important role in oxidizing fatty acids, transporting long chain fatty acids across mitochondrial membrane, and modulating intracellular coenzyme A homeostasis (3). L-Carnitine uptake into cells is mediated primarily by the organic cation/carnit...