Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within cell. Despite their low concentration, these lipids critical regulators various cellular processes, including cell cycle, differentiation, gene transcription, apoptosis and motility. PPIns generated by phosphorylation inositol head group phosphatidylinosito...

In tightly packed tissues, a cancer cell’s motility is linked to the shape of cell and its nucleus.

introduction: radiation induced bystander effect (ribe) which cause radiation effects in non-irradiated cells, has challenged the principle according to which radiation traversal through the nucleus of a cell is necessary for producing biological responses. what is the mechanism of this phenomenon? to have a better understanding of this rather ambiguous concept substantial number of original an...

Background:Leukemia is cancer of blood and bone marrow cells. In general, there are four types of leukemia: chronic myelogenous leukemia (CML), acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia (CLL) and acute lymphoblastic leukemia (ALL).  Fractal geometry can be introduced as one of the effective ways to detect this type of cancer. In this study, with introduc...

in many models of programmed cell death, the mitochondrial protein aif translocates to the nucleus, where it induces the chromatin condensation and dna degradation. however, today it is well established that this flavoprotein is bifunctional. in addition to its lethal function in the nucleus of dying cells, aif plays a vital bioenergetic role in healthy ones by regulating mainly the activity of...

Introduction: The choice of optimal radionuclides for radioimmunotherapy depends on several factors, especially the radionuclide and antibody. The dosimetric characteristics of a non-internalizing and an internalizing monoclonal antibody (MAb) labeled with beta emitting radionuclides were investigated. Methods: Using Geant4-DNA Monte Carlo simulation, we ...