Cell formation problem in Cellular Manufacturing System (CMS) design has derived the attention of researchers for more than three decades. However, use of sequence data for cell formation has been the least investigated area. Sequence data provides valuable information about the flow patterns of various jobs in a manufacturing system. This paper presents a new mathematical model to solve a cell...

This paper presents a new mathematical model for integrated dynamic cellular manufacturing systems and production planning that minimizes machine purchasing, intra-cell material handling, cell reconfiguration and setup costs. The presented model forms the manufacturing cells and determines the quantity of machine and movements  during each period of time. This problem is NP-hard, so a meta-heur...

TRPM7 (transient receptor potential melastatin 7) is a Ca²+- and Mg²+-permeant ion channel in possession of its own kinase domain. As a kinase, the protein has been linked to the control of actomyosin contractility, whereas the channel has been found to regulate cell adhesion as well as cellular Mg²+ homoeostasis. In the present study we show that depletion of TRPM7 by RNA interference in fibro...

Cell Formation (CF) is the initial step in the configuration of cell assembling frameworks. This paper proposes a new mathematical model for the CF problem considering aspects of production planning, namely inventory, backorder, and subcontracting. In this paper, for the first time, backorder is considered in cell formation problem. The main objective is to minimize the total fixed and variable...

In this paper, a robust optimization approach is proposed to design a dynamic cellular manufacturing system (DCMS) under uncertainty of processing time of products. In addition, a mathematical model considering cell formation, inter-cell design and production planning under a dynamic environment (i.e., product mix and demand are changed in each period) is presented. Therefore, reconfiguration b...

Gastrulation is a fundamental phase of animal embryogenesis during which germ layers are specified, rearranged, and shaped into a body plan with organ rudiments. Gastrulation involves four evolutionarily conserved morphogenetic movements, each of which results in a specific morphologic transformation. During emboly, mesodermal and endodermal cells become internalized beneath the ectoderm. Epibo...