membrane permeability and p-glycoprotein (p-gp) efflux system are regulating factors in the drug brain penetration. recently, some drug delivery systems have been developed to overcome these limitations. in this study, metoclopramid has been encapsulated in plga nanoparticles using the emulsification/solvent evaporation technique for in vitro evaluation of the effect of plga nanoparticles on bb...

This article evaluates the effect of membrane active channel-forming polyene antibiotic (PA) of levorin and its alkyl derivatives on the muscle performance. The membrane channels of muscle cells are capable to transport ions of potassium, sodium, and calcium. In the period of an intensive muscle exercise, the necessity for organic substrates increases and these channels start to work with the g...

A critical event in ischemia-based cell death is the opening of the mitochondrial permeability transition pore (MPTP). However, the molecular identity of the components of the MPTP remains unknown. Here, we determined that the Bcl-2 family members Bax and Bak, which are central regulators of apoptotic cell death, are also required for mitochondrial pore-dependent necrotic cell death by facilita...

This article evaluates the effect of membrane active channel-forming polyene antibiotic (PA) of levorin and its alkyl derivatives on the muscle performance. The membrane channels of muscle cells are capable to transport ions of potassium, sodium, and calcium. In the period of an intensive muscle exercise, the necessity for organic substrates increases and these channels start to work with the g...

introduction:  electroporation  is  a  technique  for  increasing  the  permeability  of  the  cell  membrane  to  otherwise  non-permeate  molecules  due  to  an  external  electric  field.  this  permeability  enhancement  is  detectable if the induced transmembrane voltage becomes greater than a critical value which depends on the  pulse  strength  threshold.  in  this  study,  the  variabil...

Introduction:  Electroporation  is  a  technique  for  increasing  the  permeability  of  the  cell  membrane  to  otherwise  non-permeate  molecules  due  to  an  external  electric  field.  This  permeability  enhancement  is  detectable if the induced transmembrane voltage becomes greater than a critical value which depends on the  pulse  strength  threshold.  In  this  study,  the  variabil...

A PEBAX-nano zeolite X mixed matrix membrane was fabricated and operationally characterized using single gas (CO2) permeation. X-ray diffraction (XRD) analysis was used to study the arrangement of polymer chains of mixed matrix membrane. The membranes were characterized by scanning electron microscopy (SEM) to study cross-sectional morphology. The single gas permeability were carried...