the neoplastic niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. these niches are important for both the maintenance of cancer stem cells and the induction of neoplastic cells survival and proliferation. each niche contains a population of tumor stem cells supported by a closely associated vascular bed compri...

there is growing evidence that lectin-carbohydrate interactions can mediate the infection of parasites to their insect vector. many insect species are host or vectors of protozoan or metazoan parasites that cause socially and economically important disease such as malaria and leishmaniasis. however, relatively little work has been undertaken concerning the interaction of insect immunity against...

Objective Bacterial adhesion is governed by specific and nonspecific interactions such as hydrophobicity. Hydrophobic interactions play a role in the adherence of microorganisms to a wide variety of surfaces and facilitate biofilm formation due to bacterial adhesion. In this article the relation between cell surface hydrophobicity and antibiotic resistance was studied. Materials and Methods ...

background: there are many studies to investigate the effects of each interacting component of tumor-immune system interactions. in all these studies, the distinct effect of each component was investigated. as the interaction of tumor-immune system has feedback and is complex, the alternation of each component may affect other components indirectly. objective: because of the complexities of tum...

recent reports have indicated different effects of immunostimulatory sequences containing cpg-oligodeoxynucleotides (odn) on various immune cells. however, the exact role of cpg-odn in the human gut is unclear. in the present study, we assessed potential effects of cpg-odn on non lymphoid cell (intestinal epithelial cell line ht-29) on a dose-response and time-course basis. intestinal epithelia...

Platinum is a metallic element, which may react with our cellular component through its involvement in cancer chemotherapy medications. Cisplatin is one of the most useful antineoplastic drugs against human ovarian carcinoma, which has the central element of platinum in its structure. The nature of chemical interaction between platinum and cellular macromolecules is yet to be understood. We exa...