BACKGROUND Oral miltefosine has been shown to be non-inferior to first-line, injectable meglumine antimoniate (MA) for the treatment of cutaneous leishmaniasis (CL) in children. Miltefosine may be administered via in-home caregiver Directly Observed Therapy (cDOT), while patients must travel to clinics to receive MA. We performed a cost-effectiveness analysis comparing miltefosine by cDOT versu...

Suppose $c_1,\ldots,c_{n+k}$ are real numbers, $\{a_1,\ldots,a_{n+k}\}\!\subset\!\mathbb{R}^n$ is a set of points not all lying in the same affine hyperplane, $y\!\in\!\mathbb{R}^n$, $a_j\cdot y$ denotes the standard real inner product of $a_j$ and $y$, and we set $g(y)\!:=\!\sum^{n+k}_{j=1} c_j e^{a_j\cdot y}$. We prove that, for generic $c_j$, the number of connected components of the real ze...

We report a nitrogen-doped carbon nanodot (N-Cdot)/TiO2 nanowire photoanode for solar-driven, real-time, and sensitive photoelectrochemical probing of the cellular generation of H2S, an important endogenous gasotransmitter based on a tunable interfacial charge carrier transfer mechanism. Synthesized by a microwave-assisted solvothermal method and subsequent surface chemical conjugation, the obt...

There is considerable overlap between the cognitive deficits observed in humans with frontal lobe damage and those described in patients with Parkinson's disease. Similar frontal impairments have been found in the 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP) primate model of Parkinsonism. Here we provide quantitative documentation of the cognitive, oculomotor, and skeletomotor dysfuncti...

To prevent the spread of tuberculosis (TB) and limit the development of drug-resistant strains, the World Health Organization and the Canadian TB Standards recommend Directly Observed Therapy (DOT) for TB patients.1,2 In Toronto, DOT is conducted by Toronto Public Health (TPH) staff who visit patients with active TB 3 to 7 days/week over the course of their treatment (i.e., 6 to 24 months) to m...

Let $ (A,| cdot |) $ be a real Banach algebra, a complex algebra $ A_mathbb{C} $ be a complexification of $ A $ and $ | | cdot | | $ be an algebra norm on  $ A_mathbb{C}  $  satisfying a simple condition together with the norm $ | cdot | $ on $ A$.  In this paper we first show that $ A^* $ is a real Banach $ A^{**}$-module if and only if $ (A_mathbb{C})^* $ is a complex Banach $ (A_mathbb{C})^{...

In this paper, we give three functors $mathfrak{P}$, $[cdot]_K$ and $mathfrak{F}$ on the category of C$^ast$-algebras. The functor $mathfrak{P}$ assigns to each C$^ast$-algebra $mathcal{A}$ a pre-C$^ast$-algebra $mathfrak{P}(mathcal{A})$ with completion $[mathcal{A}]_K$. The functor $[cdot]_K$ assigns to each C$^ast$-algebra $mathcal{A}$ the Cauchy extension $[mathcal{A}]_K$ of $mathcal{A}$ by ...

the group $2^6{{}^{cdot}} g_2(2)$ is a maximal subgroup of the rudvalis group $ru$ of index 188500 and has order 774144 = $2^{12}.3^3.7$. in this paper, we construct the character table of the group $2^6{{}^{cdot}} g_2(2)$ by using the technique of fischer-clifford matrices.