background:   brucellosis is one of the most common chronic diseases, with widespread distribution. in spite of cell-mediated immunity (cmi) modulated mainly via activated t-helper type 1 (th1) cells, brucellosis can advance to chronic disease in about 10-30% of cases. regulatory t cells (treg cells) are involved the immune response to brucellosis; however, their role, particularly in the chang...

Human natural regulatory CD4+ T cells comprise 5–10% of peripheral CD4+T cells. They constitutively express the IL-2R??chain (CD25) and nuclear transcription Foxp3. These are heterogeneous contain discrete subsets with distinct phenotypes functions. Studies in mice report that LAG-3 has a complex role cell homeostasis is expressed CD4+CD25+ In this st...

Background: Ovarian cancer is the fifth leading cause of death from malignancy in women. CD4 +CD25+FoxP3+ regulatory T (Treg) cells are a subset of T lymphocytes with great inhibitory impact on immune response. Objectives: To investigate the percentage of CD4 +CD25+FoxP3+ regulatory T cells in the peripheral blood of the Iranian patients with epithelial ovarian cancer compared to healthy women ...

Background: Atherosclerosis is a chronic inflammatory disease affecting large and medium arteries. CD4+ T cells are known to play a role in the progression of the disease. CD4+CD25+Foxp3+ natural Treg (nTreg) cells seem to have a protective role in the disease and their reduction in acute coronary syndrome is recently shown. Objective: To investigate the frequency of nTreg subsets in the pe...

background: type 1 diabetes (t1d) is a t cell mediated autoimmune disease targeting the insulin-producing β cells within pancreatic islets. autoimmune diseases may develop as a consequence of altered balance between regulatory (tregs) and autoreactive t cells. objectives: to evaluate treg cells frequency and suppressive function in the peripheral blood of newly diagnosed t1d patients in compari...

background: ovarian cancer is the fifth leading cause of death from malignancy in women. cd4 +cd25+foxp3+ regulatory t (treg) cells are a subset of t lymphocytes with great inhibitory impact on immune response. objectives: to investigate the percentage of cd4 +cd25+foxp3+ regulatory t cells in the peripheral blood of the iranian patients with epithelial ovarian cancer compared to healthy women ...

CD4(+)CD25(+) T cells are critical mediators of peripheral immune tolerance. However, many developmental and functional characteristics of these cells are unknown, and knowledge of human regulatory T cells is particularly limited. To better understand how human CD4(+)CD25(+) T cells develop and function, we examined the diversity of CD4(+)CD25(+) and CD4(+)CD25(-) T cell repertoires in both thy...

It has recently been shown that CD4(+)CD25(+) T cells are immunoregulatory T cells that prevent CD4(+) T-cell-mediated organ-specific autoimmune diseases. In this study, the regulatory mechanism of CD4(+)CD25(+) T-cell development were investigated using T-cell receptor (TCR) transgenic mice. It was found that CD4(+)CD25(+) T cells preferentially expressed the endogenous TCRalpha chain in DO10(...