objectives: immunodeficiency duo to hiv infection can produce unusual diseases in infected individuals & cd4 count is the main predictor of disease progression. in this study clinical syndromes resulting in admition, are considered according to cd4 count for the beter diagnosis and treatment of clinical problemes in hiv infected patients. materrial & methods: this is a cross - sectional...

Background & Aims: Recent evidences indicate that parts of the immunoregulation system such as CD4+CD25+Tcells (Treg) and Th2 cells and Th1 cells, play very important roles in the maintenance of pregnancy. The deficiency in proper recognition of fetal alloantigen by the maternal immune system is associated with recurrent pregnancy failure. Here, we investigate the proportional changes of CD4+CD...

background: adipose derived stem cells (ascs) provoke the accumulation and expansion of regulatory t cells, leading to the modulation of immune responses in tumor microenvironment. objective: to assess the effect of tumoral ascs on the trend of regulatory t cells differentiation. methods: peripheral blood naïve cd4+ t cells were co-cultured with ascs derived from breast cancer or normal breast ...

background: diagnosis and management of malnutrition in hiv- infected children is important as it is both a manifestation as well as an independent risk factor for death. extent in hilly poor outreach areas of north india has been poorly studied.  aim: to study the prevalence of malnutrition among children with hiv/aids using who z- score and indian academy of pediatrics (iap) method and effect...

Background: TGF-β has long been considered as the main inducer of Tregs in tumor microenvironment and is the reason for the aberrant number of Tregs in tumor-bearing individuals. Recently, it has been suggested that the enzyme arginase I is able to mediate the induction of Tregs in a TGF-β-independent fashion. The recombinant WW2/WW3 domains from smad ubiquitination regulatory factor 2 molecule...

the purpose of this study was to determine the role of streptococcal m protein in naturally-occurring cd4+cd25+ regulatory t cells (ntregs) function and development in rheumatic heart disease in iraqi patients. streptococcus pyogenes was isolated for subsequent m protein extraction. also, peripheral blood ntregs and cd4+ t cells were isolated by using magnetic cell separation system. tissue cul...