We investigated whether liver injury by dual exposure to ethanol and carbon tetrachloride (EtOH + CCl4) for 15 weeks would persist after hepatotoxic agents were removed (EtOH + CCl4/8wR). After 15 weeks of hepatic injury with ethanol (5.5%, m/v) and carbon tetrachloride (0.05, mL/kg, ip), 5 of 11 female Wistar rats were sacrificed. The other 6 rats were maintained for an additional 8 weeks with...

The study was designed to test the efficiency of of Silybum marianum in different doses to treat carbon tetrachloride (CCl4) induced liver damage. Thirty-five Wistar albino rats were divided randomly into five groups as follows: Control Group: 4 ml saline; CCl4 Group: 4 ml saline plus 2 ml/kg CCl4; 2.5% Infusion Group: 2 ml/kg CCl4 plus 2.5% infusion of Silybum marianum; 5% Infusion Group: 2 ml...

Keeping in mind the beneficial effects of GTE administration on liver damage, the present study was undertaken to evaluate the hepatoprotective effect of green tea extract (GTE) against carbon tetrachloride (CCl4)-induced liver injuries in male hamsters for 8 weeks. Twenty hamsters were equally divided into 4 groups, the control ones (group I) received only dis. water. Hamsters of group II had ...

this study aimed to evaluate the antioxidant property of chavir plant on japanese quail intoxicated with carbon tetrachloride (ccl4). eighty, one-d-old japanese quail chicks were randomly allotted to 4 treatments with 4 replicates and 5 chicks in each, using completely randomized design with 2×2 factorial arrangements including 2 levels of chavir powder (0 and 1.5 percent) and ccl4 (0 and 1 ml/...

The relative significance of gene regulation and protein isovariant differences remains unexplored for most gene families, particularly those participating in multicellular development. Arabidopsis thaliana encodes three vegetative actins, ACT2, ACT7, and ACT8, in two ancient and highly divergent subclasses. Mutations in any of these differentially expressed actins revealed only mild phenotypes...

the present study was conducted to evaluate the antioxidant effects of artichoke on liver function in broiler chicks poisoned with ccl4. a total of 60 (ross, 308) one-d-old broiler chicks were assigned into four treatments, using a completely randomized design. experimental treatments included: 1) control (received control diet), 2) artichoke (control diet supplemented with 3 percent artichoke ...

Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In this review, w...

Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in the United States and is the most commonly diagnosed non-cutaneous cancer. CCL4 is a secreted chemokine that is over expressed in patients that show PCa recurrence after prostatectomy. Currently, no reported evidence shows the biological role of CCL4 in PCa progression. We studied the role of CCL4 in PCa progre...

Male Sprague-Dawley rats were maintained on normal powdered diet or on the same diet containing 10 ppm chlordecone (CD) or 225 ppm phenobarbital (PB) for 15 days. On day 15, they received a single IP injection of a subtoxic dose of CCl4. Induction of cytochrome P-450 was greater with phenobarbital treatment than with chlordecone, but the CCl4-induced destruction of P-450 was similar in both gro...