Azole drugs selectively target fungal sterol biosynthesis and are critical to our antifungal therapeutic arsenal. However, resistance to this class of drugs, particularly in the major human mould pathogen Aspergillus fumigatus, is emerging and reaching levels that have prompted some to suggest that there is a realistic probability that they will be lost for clinical use. The dominating class of...

The objective of this study was to investigate the performance of 3 brain-computer interface (BCI) paradigms in an amyotrophic lateral sclerosis (ALS) population (n = 11). Using a repeated-measures design, participants completed 3 BCI conditions: row/column (RCW), checkerboard (CBW), and gray-to-color (CBC). Based on previous studies, it is hypothesized that the CBC and CBW conditions will resu...

BACKGROUND Antihypertensive medications are widely used among adults in the United States, and there is some evidence that certain classes may affect the risk of adverse breast cancer outcomes, but their impact on risk of second primary contralateral breast cancer (CBC) is unclear. METHODS We used data from a population-based nested case-control study consisting of 359 women diagnosed with bo...

Computer-based communication (CBC) has become an inevitable aspect of our infrastructure and a lasting alternative to face-to-face conversations. Yet, CBC (e.g. video conferencing) is not common practice for victim-offender mediation (VOM). Based on eighteen semi-structured interviews with adult victims, offenders mediators, we provide heuristic assessment applicability in VOM. Interviewees ass...

Cheyne-Stokes respiration and cardiac arrhythmias are associated with increased morbidity and mortality in patients with chronic heart failure (CHF). Enhanced carotid body chemoreflex (CBC) sensitivity is associated with these abnormalities in CHF. Reduced carotid body (CB) nitric oxide and nitric oxide synthase (NOS) levels play an important role in the enhanced CBC. In other disease models, S...

The results of a large-scale randomized controlled trial of Conjoint Behavioral Consultation (CBC) on student outcomes and teacher-parent relationships in rural schools are presented. CBC is an indirect service delivery model that addresses concerns shared by teachers and parents about students. In the present study, the intervention was aimed at promoting positive school-related social-behavio...

laparoscopic and open ovariohysterectomy were compared for the following parameters: surgical time, incision length, suture number, saturation of oxyhemoglobin (spo2), heart rate, complications,cbc findings, melbourne pain scale (mps) and gross pathology. mps pain scores were evaluated using mann-whitney u test. other parameters were evaluated using studen's t test. there were no significa...

Fluorescent probe rhodamine was appended to 5' OH-ribose of cobalamin (Cbl). The prepared conjugate, CBC, bound to the transporting proteins, intrinsic factor (IF) and transcobalamin (TC), responsible for the uptake of Cbl in an organism. Pronounced increase in fluorescence upon CBC attachment facilitated detailed kinetic analysis of Cbl binding. We found that TC had the same affinity for CBC a...

The heterotrimeric CCAAT-binding complex (CBC) is evolutionarily conserved in eukaryotic organisms, including fungi, plants, and mammals. The CBC consists of three subunits, which are named in the filamentous fungus Aspergillus nidulans HapB, HapC, and HapE. HapX, a fourth CBC subunit, was identified exclusively in fungi, except for Saccharomyces cerevisiae and the closely related Saccharomycot...