نتایج جستجو برای: cargo separation

تعداد نتایج: 133984  

This paper aims to develop a multi-objective model for scheduling cargo trains faced by the costs of tardiness and earliness, time limitations, queue priority and limited station lines. Based upon the Islamic Republic of Iran Railway Corporation (IRIRC) regulations, passenger trains enjoy priority over other trains for departure. Therefore, the timetable of cargo trains must be determined based...

Journal: :Journal of cell science 2007
Linton M Traub Gergely L Lukacs

Cargo selectivity is a hallmark of clathrin-mediated endocytosis. A wide range of structurally unrelated internalization signals specify the preferential clustering of transmembrane cargo into clathrin coats forming on the plasma membrane. Intriguingly, the classical endocytic adaptor AP-2 appears to recognize only a subset of these endocytic sorting signals. New data now reveal the molecular b...

2017
Anneri Sanger Yan Y Yip Thomas S Randall Stefano Pernigo Roberto A Steiner Mark P Dodding

The molecular interplay between cargo recognition and regulation of the activity of the kinesin-1 microtubule motor is not well understood. Using the lysosome adaptor SKIP (also known as PLEKHM2) as model cargo, we show that the kinesin heavy chains (KHCs), in addition to the kinesin light chains (KLCs), can recognize tryptophan-acidic-binding determinants on the cargo when presented in the con...

Journal: :Current Biology 2018
Eugene Jennifer Jin Ferdi Ridvan Kiral Mehmet Neset Ozel Lara Sophie Burchardt Marc Osterland Daniel Epstein Heike Wolfenberg Steffen Prohaska Peter Robin Hiesinger

Neurons are highly polarized cells that require continuous turnover of membrane proteins at axon terminals to develop, function, and survive. Yet, it is still unclear whether membrane protein degradation requires transport back to the cell body or whether degradation also occurs locally at the axon terminal, where live observation of sorting and degradation has remained a challenge. Here, we re...

Journal: :Biochimica et biophysica acta 2006
Wolfgang Schliebs Wolf-H Kunau

One feature of the PTS2 import pathway is the separation of the roles of the PTS receptor between two proteins. Pex7p alone is insufficient to act as the receptor for the import cycle for peroxisomal matrix proteins. In all cases, Pex7p needs a PTS2 co-receptor to form an import-competent PTS2 receptor complex together with the PTS2 cargo. We provide an overview of the proteins that have been i...

Amir Mohammad Kazemifar, Behnoush Ansari, Mahdi Abdollahi, Mostafa Delavar, Rita Ahmadi Araghi,

Background: Anecdotal information has suggested that sodium benzoate is used with more than permissible doses during production steps of food products especially pickles and pickled cucumbers in food producing factories in Markazi province and other food producing factories . The present study was done to evaluate factual concentration of sodium benzoate in these products. Methods: In this ...

Journal: :The EMBO journal 2010
Nicole Schueller Simon J Holton Krisztian Fodor Morlin Milewski Petr Konarev Will A Stanley Janina Wolf Ralf Erdmann Wolfgang Schliebs Young-Hwa Song Matthias Wilmanns

The protein Pex19p functions as a receptor and chaperone of peroxisomal membrane proteins (PMPs). The crystal structure of the folded C-terminal part of the receptor reveals a globular domain that displays a bundle of three long helices in an antiparallel arrangement. Complementary functional experiments, using a range of truncated Pex19p constructs, show that the structured alpha-helical domai...

Journal: :Journal of cell science 2014
Hui-Qun Phang Jing-Ling Hoon Soak-Kuan Lai Yukai Zeng Keng-Hwee Chiam Hoi-Yeung Li Cheng-Gee Koh

The kinesin motors are important in the regulation of cellular functions such as protein trafficking, spindle organization and centrosome separation. In this study, we have identified POPX2, a serine-threonine phosphatase, as an interacting partner of the KAP3 subunit of the kinesin-2 motor. The kinesin-2 motor is a heterotrimeric complex composed of KIF3A, KIF3B motor subunits and KAP3, the no...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه گیلان - دانشکده فنی 1393

asymmetric membranes are widely used in many industrial membrane separation processes. the major advantage of membrane filtration over the conventional process is its ability to remove a wider spectrum of particles without using any chemicals. hollow fiber configuration offer many advantages over flat-sheet or tubular membranes. the spinning process of hollow fiber may look simple, yet it is te...

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