Cardiopulmonary reflexes are activated via changes in cardiac filling pressure (volume-sensitive reflex) and chemical stimulation (chemosensitive reflex). The sensitivity of the cardiopulmonary reflexes to these stimuli is impaired in the spontaneously hypertensive rat (SHR) and other models of hypertension and is thought to be associated with cardiac hypertrophy. The present study investigated...

BACKGROUND Reflex anuria is an uncommon cause for acute renal failure, which occurs almost always after manipulation or irritation to kidneys, ureter, bladder or other pelvic organs. CASE PRESENTATION Here we describe a case of acute renal failure due to reflex anuria following acute cardiac event. This patient had background history of urolithiasis. In the absence of other pre renal, renal o...

Chronic heart failure (CHF) is well known to be associated with both an enhanced chemoreceptor reflex and an augmented cardiac "sympathetic afferent reflex" (CSAR). The augmentation of the CSAR may play an important role in the enhanced chemoreceptor reflex in the CHF state because the same central areas are involved in the sympathetic outputs of both reflexes. We determined whether chemical an...

By measuring blood flow in the ascending aorta with an electromagnetic flowmeter, continuous observations of cardiac output were performed in the dog during various cardiovascular reflexes. Attempts were made to analyze how changes in cardiac output and peripheral resistance contributed to each reflex. The depressor reflex to sinus nerve stimulation was attributable to three separate processes ...

We studied the reflex changes in myocardial contractility elicited by electrical stimulation of afferent cardiac sympathetic nerve fibers or chemical stimulation of their cardiac endings. Veratridine injected directly into the left coronary artery was the chemical stimulus. The maximum rate of rise of left ventricular pressure, dP/dt max, was used as an index of myocardial contractility. The st...

Neurally-mediated syncope has a broad clinical spectrum which ranges from typical vasovagal syncope on one hand, to those situations in which reflex syncope occurs with uncertain, or even apparently absent, triggers or prodromes, on the other hand. Overlap of clinical features is frequent in clinical practice and makes any classification difficult to apply when selecting patients for cardiac pa...

Previous experimental results have suggested the existence of a local cardiac reflex in the rat. In this study, the putative role of such a local reflex in cardiovascular regulation is quantitatively analyzed. A model for the local reflex is developed from anatomical experimental results and physiological data in the literature. Using this model, a systems-level analysis is conducted. Simulatio...

In previous studies we demonstrated that in normotensive rats, but not in spontaneously hypertensive rats (SHR), atrial natriuretic peptide (ANP) enhances bradycardic reflexes through an action on cardiac vagal afferent pathways. The present study aimed to determine whether cardiac hypertrophy, hypertension, or a nonreversible genetic factor accounted for the insensitivity of SHR to ANP action ...