The inception of this investigation is an exam ple of serendipity, a word recently popularized to designate the faculty of accidentally making ob servations or discoveries which were not originally sought. In the present instance, a safe antihyper tensive compound was being sought among the quinones to reduce the high blood pressure pro duced by wrapping one or both kidneys of rats with celloph...

The organ cultivation of lung tissue can be used to study the differences in the age reaction to blastomogenic action and to screen and test new carcinogenic agents, especially water-soluble substances. Comparison of the results of transplacental and immediate introduction of some blastomogenic compounds into organ cultures of the lung can provide new information on the mechanisms of their acti...

I. Patulin 409 A. Introduction 409 B. Toxicity 410 C. Cellular Effects 412 D. Biosynthesis and Biochemical Effects 413 II. Penicillic Acid 414 A. Introduction 414 B. Chemical Properties 415 C. Analysis 416 D. Biochemistry 417 E. Biological Properties 417 F. Natural Occurrence 420 II I. Other Carcinogenic Lactones 420 A. Lactones as Alkylating Agents 420 B. Five-Membered Carcinogenic Lactones 42...

This note seeks to provide an initial analysis of the strengths and weaknesses of the European Commission's impact assessment (IA) accompanying the above proposal, adopted on 10 January 2017 and referred to Parliament's Committee on Employment and Social Affairs (EMPL). The proposal intends to amend the Carcinogens and Mutagens Directive 2004/37/EC2 (CMD) by establishing binding occupational ex...

The risk of developing cancer from carcinogens occurring in food is of widespread interest to scientific researchers, food policymakers and food surveillance institutions, as well as to the general public. When evaluating the risk of carcinogenic food contaminants or carcinogenic foodstuff per se (e.g., alcoholic beverages), the level of scientific evidence should be reflected more clearly. In ...