Jackfruit contains high-value biological compounds (HVBC) with important activity in the inhibition of carcinogenesis, through various mechanisms. This study aimed to identify HVBC a methanolic fraction an extract jackfruit; which was reported antimutagenic and antiproliferative against PC3 cells (prostate cancer). The profile includes 3 organic acids, 5 phenolic 12 flavonoids, 2 carotenoids. i...

the role of oxygen free radicals in the initiation, promotion and progression of carcinogenesis and the protective role of anti-oxidant defenses has been the subject of much speculation in the recent past with conflicting reports in the literature. in recent years, increasing experimental and clinical data have provided compelling evidence for the involvement of oxidative stress in a large numb...

The article discusses modern ideas about cervical carcinogenesis as a multi-stage process of multifactorial genesis. Currently, the pathogenesis cancer (CC) are based not only on understanding role high-risk oncogenic human papillomavirus (HPV) in this and accumulation genetic changes caused by it, but also formation complex HPV interactome, or network intermolecular interactions oncoproteins w...

Experimental animals are indispensable in life science-related research, including cancer studies. After rats and mice, small fishes, such as zebrafish medaka, the second most frequently used model species. Fish models have some advantageous physical characteristics that make them suitable for their size, transparency, genetic manipulability, ease of handling, highly ortholog correspondence wit...

Heme is a crucial compound for cell survival but also equipped with the potential to be toxic and carcinogenic cells. However, recent advancement of knowledge regarding ferroptosis, iron mediated death, heme can postulated induce tumour suppression through ferroptosis. This review summarizes literature on anticarcinogenic properties specific emphasis alterations observed synthesis, metabolism t...

Medullary thyroid carcinoma (MTC) is an infrequent calcitonin-producing neuroendocrine tumor that initiates from the parafollicular C cells of the thyroid gland. Several genetic and epigenetic alterations are collaterally responsible for medullary thyroid carcinogenesis. In this review article, we shed light on all the genetic and epigenetic hallmarks of MTC. From the genetic perspective, RET, ...