UNLABELLED BACK GROUND AND THE PURPOSE OF STUDY: Sumatriptan succinate is a Serotonin 5- HT1 receptor agonist, used in treatment of migraine. It is absorbed rapidly but incompletely when given orally and undergoes first-pass metabolism, resulting in a low absolute bioavailability of about 15%. The aim of this work was to design mucoadhesive bilayered buccal tablets of sumatriptan succinate to ...

in order to formulate an efficient and durable mucoadhesive drug delivery system, careful consideration of formulation-related parameters is critical. this study was conducted to investigate the effect of the presence of various types and concentrations of surfactants within or outside carbopol 934 (c934) as well as hydroxypropylmethyl cellulose (hpmc) solid compacts, on their duration of mucoa...

The study is related to the formulation and evaluation of mucoadhesive buccal tablets Anastrozole enhance its bioavailability by avoiding 1st pass effect. succeeded in developing containing two layers (mucoadhesive backing layer) a design that permits unidirectional release drug. Tablets were prepared double direct compression method using (carbopol 934) as primary polymer, Sod.alginate, Na CMC...

Buccoadhesive tablets of carvedilol were prepared using HPMC K4M, HPMC K15M and Carbopol 934 as mucoadhesive polymers. Fifteen formulations were developed with varying concentrations of polymers. Formulations of the BC or BD series were composed of HPMC K4M or HPMC K15M in ratios of 1:1 to 1:5 whereas in the BE series Carbopol 934 was used (1:0.25 to 1:1.50). The formulations were tested for in...

Purpose: The aim of the present study was to formulate and evaluate miconazole nitrate containing thermosensitive bioadhesive gel for vaginal drug delivery to achieve a better therapeutic efficacy and patient compliance in the treatment for vaginal candidiasis. Method: Here miconazole nitrate (1%) was formulated as a vaginal gel using thermosensitive polymer, pluronic F127 (20%) along with bioa...

Inflammation is currently treated with NSAIDs. Unfortunately, these drugs increase the risk of blood clots, heart attacks, and strokes. Therefore, development potent anti-inflammatory from natural products being investigated. Natural made medicinal plants play an important role in curing many diseases associated inflammation. Conventional drug available market has various side effects. Because ...

OBJECTIVE To develop topical gel preparations of astemizole and terfenadine and to investigate the actions of the gels on the healing of incision and excision wounds in male albino rats. MATERIALS AND METHODS Gels containing 1% astemizole, with varying concentrations of carbopol 934 (polymer), were prepared. Similarly, 1% terfenadine gels were made. The formulations were evaluated for release...

The aim of current research is to develop flurbiprofen microemulsion gel for transdermal delivery. To prepare a oil, surfactant and co-surfactant selection one the important criteria. Selected different ratios oil mixture using ternary phase diagram. Based on results physicochemical properties, we have optimized formulation. formulation incorporated into carbopol P 934 base. In vitro diffusion ...