human interferons (ifns) are key cytokines secreted by immune system. they have several effects such as antiviral and anti tumors activity, activating immune cells and healing of multiple sclerosis. the type ifns present in humans are α, β and υ. ifn β is a polypeptide, normally produced by fibroblasts and seems to be more species-specific than ifn . structural properties of i fns are importan...

two capillary zone electrophoresis (cze) methods were developed in this study, one using an acidic buffer (sodium citrate ph = 2.5) and the other using a basic buffer (sodium tetraborate ph = 9.8). the two methods were compared on the basis of repeatability and reproducibility of results and the cze method developed with the basic buffer was then selected for further studies. the method was ful...

one of the problems encountered in ce separations of basic compounds is the adsorption of analytes onto the negatively charged capillary wall which could lead to poor repeatability of migration time and peak area. additionally, separation of enantiomers of chiral of basic drugs is commonly carried out in low ph buffer which contributes to strong ionic interaction of the cationic drug ions with ...

a simple and rapid stability indicating method based on capillary zone electrophoresis has been developed and validated for the analysis of buserelin (bus). the best separations were achieved by using a bare fused silica capillary (75 m i.d.; 65.5 cm total, 57.0 cm effective length), phosphate buffer (ph = 3.00; 26.4 mm), at 35 °c. the sample was hydrodynamically injected at 50 mbar for 5 seco...

background: detecting bence-jones protein in urine is essential for determining plasma cell dyscrasia and multiple myeloma. conventionally, acid-heat precipitation assay is used for detecting bence-jones protein in most medical laboratories; however, because of the low accuracy of this test, other more sensitive tests like urine electrophoresis are recommended.  materials and methods: in this s...

Capillary electrophoresis has matured into a highly sensitive and widely applied analytical method over the last forty years. Here we combine text mining computational chemistry to paint, with very broad strokes, applicability trends in scientific literature on capillary electrophoresis, simultaneously demonstrating that this is not only possible, but reveal both expected unexpected details of ...