BACKGROUND Cutaneous leishmaniasis is a health problem in the world. Lesions should be treated on cosmetically or functionally important sites, such as the face and hands. Cantharidin is a terpenoid compound produced naturally by beetles of Meloidae and Oedemeridae families. OBJECTIVES The current study aimed to investigate the effect of cantharidin on Cutaneous Leishmaniasis (CL) lesions and...

Oral cancer is a subtype of head and neck cancer which represents 2.65% of all human malignancies. Most of oral cancer is histopathologically diagnosed as oral squamous cell carcinoma (OSCC). OSCC is characterized by a high degree of local invasion and a high rate of metastasis to the cervical lymph nodes. How to prevention and treatment of OSCC is important and imperative. Here, we investigate...

In the order Coleoptera, cantharidin is produced by two families, Meloidae (true blister beetles) and Oedemeridae (false blister beetles). Cantharidin is of veterinary and medical importance, since it is super toxic to animals and humans. The present work was conducted aiming to review the cantharidin investigation and cantharidin toxicosis to animals including pathology, symptomatology, preven...

Cantharidin is an active constituent of mylabris, a traditional Chinese therapeutic agent. Cantharidin is a potent and selective inhibitor of protein phosphatase 2A (PP2A). Cantharidin has been previously reported to efficiently repress the growth of pancreatic cancer cells. However, excessively activated protein kinase C (PKC) has been shown to improve cell survival following the adminstration...

Increasing evidence suggests that tumors are composed of a heterogeneous cell population with a small subset of cancer stem cells (CSCs) that sustain tumor formation and growth, and are hypothesized to account for therapeutic resistance. Based on the expression of the surface markers CD44, CD24, and EPCAM, putative CSCs have also been identified in pancreatic cancers. It has been well establish...

background cutaneous leishmaniasis is a health problem in the world. lesions should be treated on cosmetically or functionally important sites, such as the face and hands. cantharidin is a terpenoid compound produced naturally by beetles of meloidae and oedemeridae families. objectives the current study aimed to investigate the effect of cantharidin on cutaneous leishmaniasis (cl) lesions and i...

The diamondback moth, Plutella xylostella (Linnaeus) (Lepidoptera: Plutellidae), is a major pest of cruciferous vegetables worldwide. Cantharidin, a natural toxin isolated from blister beetles, has been reported to be toxic to P. xylostella. However, little is known on the chronic sublethal effects of cantharidin on this species. In this study, we assessed the changes of susceptibility, develop...

Within the beetle family Anthicidae or ant-like flower beetles the canthariphilous species N otoxus m onoceros shows a pair o f notch-like structures on the apices o f male elytra. A reser­ voir-like swelling at the apex o f each elytron contains a bilobed gland. Its glandular tubules run into the sclerotized notch. Gaschromatographic investigations o f elytral notches and the testes o f cantha...