Canine lymphoma is a common spontaneous tumor with many similarities to human lymphoma, and thus has potential to be an important animal model of lymphomagenesis. This study determined that microRNA (miRNA) expression in canine tumors can be assessed using a commercially available human cancer miRNA qPCR array. miRNA expression in six different canine lymphoid cell lines and in naturally occurr...

Forty five lymphomas, 14 of T cell origin, 28 of B cell and 3 with null-cell phenotype, were included in this study. Tumors were classified according to the updated Kiel classification system adapted to canine lymphomas. The percentage of Ki67+ cells and mitotic index (MI) were estimated in each specimen. Most of lymphomas (39 of 45) had high proliferation activity. Among them in 27 cases 50-70...

Tumor growth depends on both proliferative and apoptotic rate of neoplastic cells. High proliferation index is a well-known negative prognostic factor in canine lymphomas, whereas little known about activity. We describe rates different lymphoma subtypes at diagnosis. Flow cytometry (FC) was used to assess the percentage proliferating cells (Ki67%) (AnnV%) 128 lymph node (LN) aspirates from dog...

The BH3-only protein Bad is a proapoptotic Bcl-2 family member that acts as a sensitizer in intrinsic apoptosis by inactivating antiapoptotic members through heterodimer formation. Bad has been shown to contribute to tumorigenesis, including lymphoma formation in humans and mice, through alteration in expression or functional status. Here, its immunohistochemical expression was analyzed in cani...

Transformation is the evolution of an indolent lymphoma/leukemia to an aggressive lymphoma, typically harboring a very poor prognosis. This phenomenon is well described in humans, but underestimated in dogs although recognized as a possible evolution of indolent lymphomas/leukemias. In canine chronic leukemias, blast crisis (mainly in myeloid) and Richter syndrome (transformation into a high gr...

BACKGROUND Canine T-cell lymphoma (TCL) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD4 TCL is reported to be the most common subtype of TCL. We assessed flow cytometric characteristics, histologic features when available, and clinical outcomes of CD4+ TCL to determine if flow cytometry can be used to subclassify this group of l...

Abstract Lymphoma is a malignant tumor commonly diagnosed in dogs representing 7–24% of all canine tumors. There has been no previous studies focused on characterization lymphoma cases Latvia. The goals this retrospective study were to determine prevalence and characteristics among biopsy submissions private veterinary pathology service that receives approximately 80% submission Latvia compare ...

s of invited lectures Workshop Proceedings Page 5 Abstracts of invited lectures SESSION ON PATHOGENESIS Chairs: Hugo Murua Escobar, Franco Guscetti 01 Comparative Transcriptional Analysis of Canine and Human Diffuse Large B Cell Lymphoma (DLBCL). Molecular Signatures of NF-κB Activation and Sub-Classification of DLBCL Ted Hupp Edinburgh Cancer Research UK Centre, Edinburgh, United Kingdom E-mai...