The distribution of calretinin immunoreactivity in the developing olfactory system of the rainbow trout was studied by using an indirect immunocytochemical method. Calretinin immunoreactivity was firstly detected at 150 day-degrees in the olfactory placode, where labeled primordial cells were observed. At 250 day-degrees, precursor cells of the olfactory receptor neurons located in the olfactor...

Objective: To investigate the relationship between primary epithelial ovarian tumors and histomorphologic changes in fimbrial ends (FEs) of fallopian tubes. Materials Methods: Twenty-eight serous carcinomas (SCs) 12 non-serous (NSC) were studied. Ovarian concomitant invasive FEs labeled with PAX8, WT-1 Calretinin. Results: Eighty-six percent SCs high grade (HG), 14% low (LG). 71% (85% HG, 15% L...

In the mammalian neocortex, the calcium-binding protein calretinin is expressed in a subset of cortical interneurons. In the recent years, research on interneurons is one of the most rapidly growing fields in neuroscience. This review summarizes the actual knowledge of the functions of calretinin in neuronal homeostasis and particularly of the distribution, connectivity and physiological proper...

Ca(2+)-binding proteins of the EF-hand family are widely expressed in the CNS, and contribute to intracellular Ca(2+) buffering in neurons. In nerve terminals, Ca(2+)-binding proteins are likely to regulate transmitter release probability and synaptic short-term-plasticity. Here, we investigated the developmental expression pattern of calretinin and parvalbumin at a large excitatory synapse, th...

BACKGROUND Hirschsprung disease is a complex genetic disorder of the enteric nervous system (ENS), often called congenital aganglionic megacolon and characterized by the absence of enteric neurons along a variable length of the intestine. The definitive diagnosis of Hirschsprung disease relies on histologic and/or histochemical staining of sections from suction rectal biopsies. Calretinin immun...

Calretinin is a calcium-binding protein which participates in a variety of functions including calcium buffering and neuronal protection. It also serves as a developmental marker of retinal ganglion cells (RGCs). In order to study the role of calretinin in the development and regeneration of RGCs, we have studied its pattern of expression in the retina at different developmental stages, as well...

We studied calretinin-immunoreactive (IR) fibers and cells in the canine superior colliculus (SC) and studied the distribution and effect of enucleation on the distribution of this protein. Localization of calretinin was immunocytochemically observed. A dense plexus of anti--calretinin-IR fibers was found within the upper part of the superficial gray layer (SGL). Almost all of the labeled fiber...

Breast carcinoma is the second most common cancer following lung cancer. The incidence of accounts for 24.2% and death about 15% among females. There are various prognostic predictive factors assessing patient encountering breast. Among factors, histological subtype molecular play a key role. calretinin expression in breast was seen high-grade carcinomas basal like Calretinin predominantly note...

The present study describes the distribution and structural features of calretinin-immunoreactive neurons and fiber plexuses in the cerebral cortex of a lacertid lizard, at the light and electron microscopic levels, and also examines the colocalization of calretinin with parvalbumin and gamma-aminobutyric acid (GABA) in certain cortical regions. Calretinin-immunoreactive neurons are present thr...

Granular cell tumors (GCTs) typically express S-100 protein, which has been used as a marker in differential diagnosis. Calretinin, a calcium-binding protein related structurally to S-100, and inhibin, a polypeptide hormone secreted primarily by ovarian granulosa cells and testicular Sertoli cells and functioning as an inhibitor for pituitary follicle-stimulating hormone secretion, are potentia...