نتایج جستجو برای: calpain

تعداد نتایج: 5210  

2012
M Niapour C Farr M Minden S A Berger

Calpains are intracellular cysteine proteases that have crucial roles in many physiological and pathological processes. Elevated calpain activity has been associated with many pathological states. Calpain inhibition can be protective or lethal depending on the context. Previous work has shown that c-myc transformation regulates calpain activity by suppressing calpastatin, the endogenous negativ...

Journal: :American journal of physiology. Cell physiology 2008
Michiyo Honda Fujiko Masui Nobuyuki Kanzawa Takahide Tsuchiya Teruhiko Toyo-oka

Fusion of mononuclear myoblast to multinucleated myotubes is crucial for myogenesis. Both mu- and m-calpain are ubiquitously expressed in most cells and are particularly abundant in muscle cells. Knockout of calpain-1 (catalytic subunit of mu-calpain) induced moderate platelet dysaggregation, preserving the normal development and growth, although knockout of calpain-2 (m-calpain) is lethal in m...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2010
Sohila Zadran Hussam Jourdi Karoline Rostamiani Qingyu Qin Xiaoning Bi Michel Baudry

Calpain is a calcium-dependent protease that plays a significant role in synaptic plasticity, cell motility, and neurodegeneration. Two major calpain isoforms are present in brain, with mu-calpain (calpain1) requiring micromolar calcium concentrations for activation and m-calpain (calpain2) needing millimolar concentrations. Recent studies in fibroblasts indicate that epidermal growth factor (E...

2013
Venkateswaran Subramanian Jessica J. Moorleghen Anju Balakrishnan Deborah A. Howatt Athar H. Chishti Haruhito A. Uchida

BACKGROUND AND OBJECTIVE Recently, we demonstrated that angiotensin II (AngII)-infusion profoundly increased both aortic protein and activity of calpains, calcium-activated cysteine proteases, in mice. In addition, pharmacological inhibition of calpain attenuated AngII-induced abdominal aortic aneurysm (AA) in mice. Recent studies have shown that AngII infusion into mice leads to aneurysmal for...

Journal: :The Journal of biological chemistry 2007
Ronald L Mellgren Xinhua Huang

Yeast two-hybrid experiments identified alpha(2)-Heremans-Schmid glycoprotein (human fetuin A) as a binding partner for calpain domain III (DIII). The tandem DIIIs of calpain-10 interacted under the most selective culture conditions, but DIIIs of m-calpain, calpain-3, and calpain-5 also interacted under less stringent selection. DIIIs of mu-calpain, calpain-6, and the tandem DIII-like domains o...

Journal: :Cardiovascular research 2009
Ying Li Yanwen Li Qingping Feng Malcolm Arnold Tianqing Peng

AIMS Cardiomyocyte apoptosis contributes to cardiac complications of diabetes. The aim of this study was to investigate the role of calpain in cardiomyocyte apoptosis induced by hyperglycaemia. METHODS AND RESULTS In cultured adult rat ventricular cardiomyocytes, high glucose (33 mM) increased calpain activity and induced apoptosis, concomitant with the impairment of Na+/K+ ATPase activity. T...

Journal: :Clinical and experimental pharmacology & physiology 2010
Robyn M Murphy

1. Skeletal muscle fibres contain ubiquitous (mu-calpain and m-calpain) and muscle-specific (calpain-3) Ca(2+)-dependent proteases. The physiological roles of the calpains are not well understood, although ubiquitous calpains have been associated with apoptosis and myogenesis and calpain-3 is likely involved in sarcomeric remodelling. A defect in the expression of calpain-3 results in limb-gird...

Journal: :Neuron 2007
Fei Chen Lei Qian Zhi-Hua Yang Ying Huang Shyuan T. Ngo Nan-Jie Ruan Jia Wang Claudio Schneider Peter G. Noakes Yu-Qiang Ding Lin Mei Zhen-Ge Luo

Agrin induces, whereas acetylcholine (ACh) disperses, ACh receptor (AChR) clusters during neuromuscular synaptogenesis. Such counteractive interaction leads to eventual dispersal of nonsynaptic AChR-rich sites and formation of receptor clusters at the postjunctional membrane. However, the underlying mechanisms are not well understood. Here we show that calpain, a calcium-dependent protease, is ...

Journal: :The Biochemical journal 1984
N Yoshimura I Tsukahara T Murachi

Two forms of Ca2+-dependent cysteine proteinase (calpain, EC 3.4.22.17) and their specific endogenous inhibitor (calpastatin) were partially purified from porcine retina: calpain I (low-Ca2+-requiring form) was half-maximally activated at 8 microM-Ca2+, and calpain II (high-Ca2+-requiring form) at 250 microM-Ca2+. Both calpain I and calpain II were inhibited by calpastatin. Calpain I from porci...

Journal: :Microvascular research 2009
Houxiang Hu Xiaoping Li Ying Li Lefeng Wang Sanjay Mehta Qingping Feng Ruizhen Chen Tianqing Peng

This study was to investigate the role of calpain in the apoptosis of pulmonary microvascular endothelial cells (PMEC) during septic plasma stimulation. Septic plasma was collected from endotoxemic mice. In cultured PMEC, incubation with septic plasma stimulated calpain activation, increased caspase-3 activity and induced apoptotic cell death. These effects of septic plasma were abrogated by kn...

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