Rearrangements involving the MLL gene at chromosome band 11q23 are common in infant acute myeloid leukemias (AMLs). We recently encountered an infant patient with rapidly progressive AML whose leukemic cells harbored a previously undescribed MLL rearrangement involving an inversion of 11q [inv(11)(q14q23)]. We used panhandle PCR to determine that this rearrangement juxtaposed the MLL (Mixed-Lin...

Chronic stress is associated with negative health outcomes and is linked with neuroendocrine changes, deleterious effects on innate and adaptive immunity, and central nervous system neuropathology. Although stress management is commonly advocated clinically, there is insufficient mechanistic understanding of how decreasing stress affects disease pathogenesis. Therefore, we have developed a "cal...

European Americans value excitement more and calm less than Chinese. Within cultures, European Americans value excited and calm states similarly, whereas Chinese value calm more than excited states. To examine how these cultural differences influence people's immediate responses to excited vs calm facial expressions, we combined a facial rating task with functional magnetic resonance imaging. D...

The CALM-AF10 fusion gene, which results from a t(10;11) translocation, is found in a variety of hematopoietic malignancies. Certain HOXA cluster genes and MEIS1 genes are upregulated in patients and mouse models that express CALM-AF10. Wild-type clathrin assembly lymphoid myeloid leukemia protein (CALM) primarily localizes in a diffuse pattern within the cytoplasm, whereas AF10 localizes in th...

15 Rice cleaning I 16 Wheat grinding Strong on left 28th, 29th; windy 30th. High wind 6th, 10th, llth; calm 12th. Calm weather. Ditto. Nov. 29th windy ; 30tli calm. Windy two days previously. Calm after wind on llth, 12tli Feb. Windy on 14th, 15th, 16th. 2nd Mar. windy; 3rd fine; 4th windy. Ditto. May 4th?6th very windy. May 24th, 25th windy. May 2dth, windy. June 3rd, 4th sultry ; June 5th, hi...

Music emotion recognition and recommendation systems often use a simplified 4-quadrant model with categories such as Happy, Sad, Angry, and Calm. Previous research has shown that both listeners and automated systems often have difficulty distinguishing low-arousal categories such as Calm and Sad. This paper seeks to explore what makes the categories Calm and Sad so difficult to distinguish. We ...

Consensual and regionally distinct features of well-being and self were examined in a nationally representative survey of midlife Americans (ages 25-75). Consistent with key American ideology, Study 1 found that a majority of Americans believe they have high levels of mastery, purpose, life satisfaction, overall health, family and work obligation, and partner and family support. Study 2 found d...