نتایج جستجو برای: cadm

تعداد نتایج: 76  

2017
Ashutosh Sharma Marie Hudson Kevin Watters Robin Billick Sabrina Fallavolita Elena Netchiporouk

ART: antiretroviral therapy CADM: clinically amyopathic dermatomyositis DM: dermatomyositis ILD: interstitial lung disease MDA5: melanoma differentiationeassociated protein 5 MFU: median fluorescence units INTRODUCTION Dermatomyositis (DM) is an idiopathic inflammatory myopathy that can affect children and adults and is characterized by muscle inflammation and characteristic cutaneous findings....

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2014
Shinji Sato Shinichi Nogi Noriko Sasaki Naofumi Chinen Kiri Honda Eiko Saito Takayuki Wakabayashi Chiho Yamada Yasuo Suzuki

Here, we report a patient with sarcoidosis who developed edematous erythema and interstitial lung disease. At the initial visit, clinically amyopathic dermatomyositis (CADM) with rapidly progressive interstitial lung disease (RP-ILD) was suspected because he had progressive dyspnea but no muscle weakness. The presence of anti-CADM-140/MDA5 autoantibodies was immediately assessed to facilitate a...

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2015
Atsushi Komatsuda Ayumi Omokawa Masaru Togashi Shin Okuyama Ken-ichi Sawada Hideki Wakui

Objectives Clinically amyopathic dermatomyositis (CADM) is considered as the subtype of dermatomyositis with amyopathy or hypomyopathy. Rapidly progressive interstitial lung disease (RP-ILD) is treatment-resistant and life-threatening in patients with CADM. Since useful markers for early diagnosis are necessary for early treatment in CADM patients with RP-IPD, this study aimed to investigate th...

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2018
Alfredo Agulló Brian Hinds Mónica Larrea Ignacio Yanguas

Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) that has conventional cutaneous manifestations of DM, but paradoxically, little or no muscle involvement. In 2005, a novel antibody was described in association with CADM - anti-melanoma differentiation-associated gene 5 (anti-MDA5). Patients with this serologic marker have a characteristic mucocutaneous phenotype ...

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2014
Ilyas Alper Karatepe Engin Zeydan

Anomaly detection is a key component in which perturbations from a normal behavior suggests a misconfigured/mismatched data in related systems. In this paper, we present a call detail record based anomaly detection method (CADM) that analyzes the users’s calling activities and detects the abnormal behavior of user movements in a real cellular network. CADM is capable of detecting the location o...

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Journal: :BMC pulmonary medicine 2015
Satoshi Ikeda Machiko Arita Mitsunori Morita Satoshi Ikeo Akihiro Ito Fumiaki Tokioka Maki Noyama Kenta Misaki Kenji Notohara Tadashi Ishida

BACKGROUND Interstitial lung disease (ILD) associated with clinically amyopathic dermatomyositis (CADM-ILD) is often refractory and rapidly progressive. Although the anti-melanoma differentiation-associated gene 5 (anti-MDA-5) antibody is associated with rapidly progressive ILD (RP-ILD), differences in clinical features and prognosis of anti-MDA-5 antibody-positive and -negative CADM-ILD remain...

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2017
Hiroko Okabayashi Hidenori Ichiyasu Sayuri Hirooka Kimitaka Akaike Keisuke Kojima Takayuki Jodai Yasumiko Sakamoto Hideharu Ideguchi Shohei Hamada Chieko Yoshida Susumu Hirosako Shinichiro Okamoto Hirotsugu Kohrogi

BACKGROUND Rapidly progressive interstitial pneumonias (RPIPs) associated with clinically amyopathic dermatomyositis (CADM) are highly resistant to therapy and have a poor prognosis. Multimodal therapies, including direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP), have a protective effect on RPIPs. We evaluated the effects of PMX-DHP on CADM-associated RPIPs. METHOD...

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Journal: :AANA journal 2008
Vicki C Coopmans Chuck Biddle

Directives to improve patient outcomes and enhance safety within the healthcare system have led to development of technologies to assist practitioners in a variety of activities. The purpose of this study was to explore and evaluate a method for examining the effect of computer-assisted decision making (CADM) using a handheld device on the accuracy (ie, correct diagnosis and treatment) and spee...

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2011
Yoshinao Muro Kazumitsu Sugiura Kei Hoshino Masashi Akiyama Koji Tamakoshi

INTRODUCTION Several reports have found the onset or activity of inflammatory myopathies to show spatial clustering and seasonal association. We recently detected autoantibodies against melanoma differentiation-associated gene 5 (MDA-5) in more than 20% of patients with dermatomyositis. Anti-MDA-5 antibodies were associated with the presence of rapidly progressive interstitial lung disease in c...

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Journal: :Rheumatology 2012
Tomohiro Koga Keita Fujikawa Yoshiro Horai Akitomo Okada Shin-Ya Kawashiri Naoki Iwamoto Takahisa Suzuki Yoshikazu Nakashima Mami Tamai Kazuhiko Arima Satoshi Yamasaki Hideki Nakamura Tomoki Origuchi Yasuhito Hamaguchi Manabu Fujimoto Yuji Ishimatsu Hiroshi Mukae Masataka Kuwana Shigeru Kohno Katsumi Eguchi Kiyoshi Aoyagi Atsushi Kawakami

OBJECTIVE Interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD), is a major poor prognostic factor in patients with DM. We investigated the association of anti-melanoma differentiation-associated gene 5 (MDA5) antibody (Ab) with clinical characteristics and mortality in Japanese patients with DM. METHODS Seventy-nine DM patients, comprising 58 classic DM and 21 clinicall...

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