Computer-aided drafting and design (CADD) is a computer-based program that improves the efficiency of product design and components both inside and outside of engineering. In recent years the use of CADD in dentistry, more commonly known as computer-aided dentistry, has become commonplace, allowing doctors and patients to individually design treatment with the result visible through computer-ge...

PIEB has been reported as being superior to CEI for labor analgesia. The aim of this study was to measure the pressures generated by two commercially available pumps (CADD PIB, Smiths and Gemstar, Hospira) when delivering PIEB or CEI at 2 commonly used rates of infusion (10 or 5 mL). The two pumps were set to deliver fluid at four rates (CEI: 5 or 10 mL/h; PIEB: 5 or 10 mL every h) and connecte...

A cadmium resistance gene, designated cadD, has been identified in and cloned from the Staphylococcus aureus plasmid pRW001. The gene is part of a two-component operon which contains the resistance gene cadD and an inactive regulatory gene, cadX*. A high degree of sequence similarity was observed between cadD and the cadB-like gene from S. lugdunensis, but no significant similarity was found wi...

This paper reports a system for automatic extraction of geometric and non-geometric part information from `engineering drawings' created using computer-aided design and drafting (CADD) tools. A heuristic search is employed to interpret the characteristic attributes of dimension sets that denote linear, diametrical, radial and angular dimensions. Textual callouts are processed using natural lang...

This article recounts the development of a stand-alone CAD platform, the IDIIOM. The IDIIOM was developed during the mid-1960s at Information Displays, Inc. (IDI), then in Mt. Vernon, N.Y. According to its creators, the IDIIOM was the first general-purpose design workstation, the first commercial CADD platform, and the first software drafting package to operate on its own computer without commu...

BACKGROUND The success of collapsing methods which investigate the combined effect of rare variants on complex traits has so far been limited. The manner in which variants within a gene are selected prior to analysis has a crucial impact on this success, which has resulted in analyses conventionally filtering variants according to their consequence. This study investigates whether an alternativ...

BACKGROUND Diabetes is a metabolic disorder that requires multiple therapeutic approaches. The pancreas loses its functionality to properly produce the insulin hormone in patients with diabetes mellitus. In 2012, more than one million people worldwide died as a result of diabetes, which was the eighth leading cause of death. OBJECTIVE Most drugs currently available and approved by the U.S. Fo...

Computer-aided drug design (CADD) is an interdisciplinary subject, playing a pivotal role during new drug research and development, especially the discovery and optimization of lead compounds. Traditional Chinese Medicine (TCM) modernization is the only way of TCM development and also an effective approach to the development of new drugs and the discovery of potential drug targets (PDTs). Disco...