نتایج جستجو برای: cad pathogenesis
تعداد نتایج: 143211 فیلتر نتایج به سال:
The aim of the present study was to identify the genetic defect responsible for familial coronary artery disease/myocardial infarction (CAD/MI), which exhibited an autosomal dominant pattern of inheritance, in an extended Chinese Han pedigree containing 34 members. Using exome and Sanger sequencing, a novel 6‑base pair (bp) 'CAGCCG' deletion in exon 11 of the myocyte enhancer factor 2A (MEF2A) ...
The last 2 decades have seen great progress in understanding the pathogenesis of cold agglutinin disease (CAD) and development effective therapies. Cold agglutinins can cause hemolytic anemia as well peripheral circulatory symptoms such acrocyanosis. We distinguish CAD, a well-defined clinicopathologic entity, from secondary syndrome. This review addresses histopathologic, immune phenotypic, mo...
OBJECTIVE Defects in angiogenesis/vasculogenesis or vessel repair are major complications of coronary artery disease (CAD). Endothelial progenitor cells (EPCs) play a fundamental role in postnatal vascular repair and CAD. The role of microRNAs in CAD pathogenesis and their potential as biomarkers remain to be elucidated. APPROACH AND RESULTS MicroRNA-31 (miR-31) level in both the plasma and E...
Lymphotoxin-alpha (LTA), a pro-inflammatory cytokine, has been implicated in the pathogenesis of coronary atherosclerosis. Meanwhile, association of some single nucleotide polymorphisms (SNPs) of LTA gene with coronary artery disease (CAD) has been evaluated; however, the results are irreproducible. We therefore investigated the relationship between four SNPs of LTA gene and CAD in Han Chinese:...
We performed a meta-analysis of 4 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 3 loci newly associated with CAD at P < 5 × 0−8 and confirmed the association of 0 of 2 previously rep...
Background: Low density lipoprotein (LDL) particles have shown to be heterogeneous structures with distinctive electrical charges. Alteration in the fatty acids content of the LDL particles is known to affect their structural features, electrical charges, and ultimately physiologic properties and, in this way, may play a role in the pathology of coronary artery disease (CAD). On the basis of ev...
Pro oxidant and antioxidant status in patients with coronary artery disease proven angiographic ally
Introduction: Coronary artery disease (CAD) is the major cause of death in both industrial and developing countries. Evidences suggest that increase in free radical generation and/or attenuated antioxidant defenses may be involved in the pathogenesis of CAD. The aim of this investigation was to evaluate the plasma measures of oxidative stress in patients with coronary artery disease documente...
Aim: To investigate the association between the paraoxonase 1 (PON1) c.163T>A and c.575A>G polymorphisms and coronary artery disease (CAD), and whether specifi c polymorphisms in the PON1 gene are associated with CAD in the southeastern Turkish population. Many diff erent genetic and clinical factors have been identifi ed as causes or contributors to atherosclerosis. Complex diseases such as CA...
Cervical artery dissection (CAD) represents an increasingly recognized cause of stroke and the most common cause of ischemic stroke in young adults. Many factors have been identified in association with CAD such as primary disease of arterial wall (fibrodysplasia) and other non-specific diseases related to CAD like Ehlers Danlos-syndrome IV, Marfan's syndrome, vessel tortuosity. Moreover, an un...
Tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6) are involved in the progression of coronary artery disease (CAD). The cytokines’ levels are associated with the severity of CAD. We have recently reported on the association of resistin, a relatively novel cytokine with the pathogenesis of cardiovascular disease (CVD). Although the inflammatory cytokines’ impact on atherosclerosis...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید