نتایج جستجو برای: cacna2d1
تعداد نتایج: 28 فیلتر نتایج به سال:
AIM To identify differentially expressed microRNAs in medulloblastoma, and to investigate their biological function. MATERIAL AND METHODS Differentially expressed microRNAs were identified using gene chips, and significantly different microRNAs were selected for verification using real time quantitative PCR. Potential target genes and their biological pathways were predicted by bioinformatics...
Genomic aberrations of the CACNA2D1 gene in three patients with epilepsy and intellectual disability
Peripheral T cell lymphoma (PTCL) is a heterogeneous malignancy with poor response to current therapeutic strategies and incompletely characterized genetics. We conducted whole exome sequencing of matched PTCL and non-malignant samples from 12 patients, spanning 8 subtypes, to identify potential oncogenic mutations in PTCL. Analysis of the mutations identified using computational algorithms, CH...
Introduction Early repolarization (ER) is a common electrocardiographic finding and is diagnosed by the presence of a J-wave amplitude of Z0.1 mV in Z2 contiguous inferior or lateral leads of a standard 12-lead electrocardiogram (ECG), which is manifested as QRS slurring or notching. The ER pattern is observed in 1%–13% of cases in the general population and is mainly thought to be benign. Howe...
More than 300 variants in 12 genes have been associated with Brugada syndrome (BrS) which has a prevalence ranging between 1:2000 and 1:100,000. Until recently, there has been little knowledge regarding the distribution of genetic variations in the general population. This problem was partly solved, when exome data from the NHLI GO Exome Sequencing Project (ESP) was published. In this study, we...
Hypoxia preconditioning is an effective strategy of intrinsic cell protection. An acute repetitive hypoxic mice model was developed. High-throughput microarray analysis was performed to explore the integrative alterations of gene expression in repetitive hypoxic mice. Data obtained was analyzed via multiple bioinformatics approaches to identify the hub genes, pathways and biological processes r...
Huge livestock population of India is under threat by a large number of endemic infectious (bacterial, viral, and parasitic) diseases. These diseases are associated with high rates of morbidity and mortality, particularly in exotic and crossbred cattle. Beside morbidity and mortality, economic losses by these diseases occur through reduced fertility, production losses, etc. Some of the major in...
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