BACKGROUND Investigation of a 61-year-old Caucasian male suffering from fatigue and weight loss led to the finding of a carbohydrate antigen 19-9 (CA 19-9) concentration of 80 kU/L using an ADVIA Centaur analyser. Determination of CA 19-9 on Vidas, AxSYM and Architect i2000 systems gave normal results. His rheumatoid factor concentration was very high (900 kIU/L) and assay interference was susp...

BACKGROUND CA19-9 was evaluated as a prognostic marker for colorectal cancer and whether it could be helpful in addition to surveillance using CEA was also tested. MATERIALS AND METHODS Serum CA19-9 levels were measured preoperatively in 1109 patients and monitored at 3-month intervals for the first 2 years postoperatively, and at 6-month intervals thereafter in 700 patients. RESULTS Preope...

BACKGROUND Serum carbohydrate antigen 19-9 (CA 19-9) has been shown to be a sensitive and specific serum marker for pancreatic cancer. Little has been published about correlations between baseline CA 19-9 level or changes to CA 19-9 level and median overall survival (mOS). Its impact on monitoring treatment efficacy remains under discussion, however. METHODS CA 19-9 serum level was measured i...

In a human challenge experiment, the infectivity of gonococci with sialylated lipooligosaccharide (LOS) was compared with the infectivity of gonococci with unsialylated LOS. Volunteers were intraurethrally inoculated with approximately 5000 sialylated or unsialylated piliated, non-opaque (P+Opa-, transparent) colony type gonococci, strain MS11mkC. Five (83%) of 6 volunteers inoculated with unsi...

The low prevalence of pancreatic cancer remains an obstacle to the development of effective screening tools in an asymptomatic population. However, development of effective serologic markers still offers the potential for improvement of diagnostic capabilities, especially for subpopulations of patients with high risk for pancreatic cancer. The accurate identification of patients with pancreatic...

Although CA 19-9 is a tumour marker, high levels of CA 19-9 have also been reported in benign conditions such as acute cholangitis or pancreatitis. We present here a 56-year-old woman with complicated cholecystitis due to gallstone and elevated serum CA19-9 levels. After cholecystectomy procedure CA19-9 level returned to normal. The level of CA 19-9 should never be regarded as a gold standard b...

between CA-19-9 concentrations in blood and whether or not patients were taking supplements. Thus, cystic fibrosis is one of the first benign diseases shown to be associated with high CA-19-9 concentrations in blood. The origin of CA-19-9 in these patients instill unknown. it is unlikely to be derived from the pancreas because patients with pancreatitis reportedly have low concentrations of thi...

Changes to the glycan structures of proteins secreted by cancer cells are known to be functionally important and to have potential diagnostic value. However, an exploration of the population variation and prevalence of glycan alterations on specific proteins has been lacking because of limitations in conventional glycobiology methods. Here we report the use of a previously developed antibody-le...

OBJECTIVE Interaction of CA19-9 with E-selectin is involved in initiation of hematogenous metastases. We investigated whether serum concentrations of E-selectin and CA19-9 are good predictors of hematogenous metastases and prognosis in colorectal cancer. METHODS Pre-operative serum samples were obtained from 152 patients with colorectal cancer, and from 28 healthy volunteers. Correlation betw...

INTRODUCTION Serum carbohydrate associated antigen (CA19-9) is widely used marker in clinical practice and shows small increases in a few benign diseases. Here we report two cases, a mother and her daughter with slightly elevated CA19-9 levels not accompanied by any clinical pathology. CASE PRESENTATION The mother with elevated CA19-9 level (89.90 U/mL; upper limit of normal range (ULNR) < 37...