نتایج جستجو برای: c677t

تعداد نتایج: 1675  

2013
Wenju Wang Zongliu Hou Chunhui Wang Chuanyu Wei Yaxiong Li Lihong Jiang

BACKGROUND Inconsistent results were reported in recent literature regarding the association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and the susceptibility of congenital heart disease (CHD). In this study, we performed a meta-analysis to investigate the associations by employing multiple analytical methods. METHODS Literature search was performed and pub...

Journal: :Acta medica Iranica 2012
Navid Nilforoushan Sevil Aghapour Reza Raoofian Samira Saee Rad Wayne K Greene Ghasem Fakhraie Mansour Heidari

Glaucoma is a major cause of blindness worldwide. A single nucleotide polymorphism of the MTHFR gene (C677T) has been associated with susceptibility to this disease, although this is controversial in the last decade. In this study, the possible association between the MTHFR C677T polymorphism and the risk of developing primary open angle (POAG) and pseudoexfoliation glaucoma (PEXG) was investig...

Journal: :Seizure 2014
Yi-Le Wu Hui-Yun Yang Xiu-Xiu Ding Xue Zhao Jian Chen Peng Bi Ye-Huan Sun

PURPOSE Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has been implicated as a potential risk factor for epilepsy. To date, many case-control studies have investigated the association between MTHFR C677T polymorphism and epilepsy susceptibility. However, those findings were inconsistent. The objective of this study is to evaluate the precise association between MTHFR C677T poly...

2014
Shashank Gupta Pradeep Kumar Bhaskar Ritu Bhardwaj Abhishek Chandra Vidya Nair Chaudhry Prashaant Chaudhry Akhtar Ali Ashim Mukherjee Mousumi Mutsuddi

Hyperhomocysteinemia induced by the C677T genetic variant in MTHFR (methylenetetrahydrofolate reductase) has been implicated in neuronal cell death of retinal ganglion cells (RGC), which is a characteristic feature of glaucoma. However, association of MTHFR C677T with glaucoma has been controversial because of inconsistent results across association studies. Association between MTHFR C677T and ...

2011
S. Kimi Uehara

Sugérese que la hiperuricema sea un factor de riesgo cardiovascular en humanos adultos con síndrome metabólico (SM) El polimorfismo C677T en el gen metilenotetrahidrofolato reductasa (MTHFR) ha sido asociado com la hiperuricemia. Datos sobre los factores asociados con la uricemia en humanos adultos con SM genotipados para el polimorfismo C677T en el gen MTHFR son inexistentes. Se objetivó inves...

2013
Min-Ho Shin Jin-Su Choi Jung-Ae Rhee Young-Hoon Lee Hae-Sung Nam Seul-Ki Jeong Kyeong-Soo Park Hye-Yeon Kim So-Yeon Ryu Seong-Woo Choi Hye-Rim Song Hee Nam Kim Jane A. Cauley Sun-Seog Kweon

The purpose of this study was to examine the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and bone mineral density (BMD). Two large cohort studies were performed: the Dong-gu Study (3,621 men and 5,409 women) and the Namwon Study (3,703 men and 5,672 women). We assessed lumbar spine and femoral neck BMD by dual-energy X-ray absorptiometry. Genotypes wer...

Journal: :European heart journal 1999
A Gardemann H Weidemann M Philipp N Katz H Tillmanns F W Hehrlein W Haberbosch

BACKGROUND There are conflicting results on the relationship of N5,N10-methylenetetrahydrofolate reductase C677T gene variation in coronary artery disease and myocardial infarction. METHODS AND RESULTS We analysed this gene variation in 2453 male Caucasians whose coronary anatomy was defined by coronary angiography. In the total sample, the C677T gene polymorphism was not associated with the ...

Journal: :Cancer genomics & proteomics 2009
Chiu-Shong Liu Chia-Wen Tsai Te-Chun Hsia Rou-Fen Wang Chin-Jung Liu Liang-Wen Hang Su-Yin Chiang Chung-Hsing Wang Ru-Yin Tsai Cheng-Chieh Lin Da-Tian Bau

UNLABELLED The aim of this study was to evaluate the association and interaction of genotypic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and environmental factors with lung cancer in Taiwan. Two well-known polymorphic variants of MTHFR, C677T (rs1801133) and A1298C (rs1801131), were analyzed in association with lung cancer susceptibility, and discussed their joint effects with...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 1999
D L Harmon R M Doyle R Meleady M Doyle D C Shields R Barry D Coakley I M Graham A S Whitehead

Mild hyperhomocysteinemia is a risk factor for atherosclerotic vascular disease. Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, and has been directly associated with cardiovascular disease in certain populations. The purpose of th...

ژورنال: :کومش 0
موگه حاج اسمعیلی mogge hajiesmaeil dept. of biology, faculty of biological sciences, parand branch, islamic azad university, parand, iran- گروه زیست شناسی، دانشکده علوم زیستی، واحد پرند، دانشگاه آزاد اسلامی، پرند، ایران فرزانه تفویضی farzaneh tafvizi dept. of biology, parand branch, islamic azad university, parand, iran- گروه زیست شناسی، واحد پرند، دانشگاه آزاد اسلامی، پرند، ایران سهیلا سرمدی soheila sarmadi dept. of pathology, tehran university of medical science, tehran, iranگروه پاتولوژی، دانشگاه علوم پزشکی تهران، تهران، ایران

سابقه و هدف: سرطان دهانه رحم یکی از سرطان های شایع در زنان می باشد. فاکتورهای متعددی در ابتلا به این سرطان نقش دارند که می توان به عفونت پاپیلوما ویروس (hpv)، تغییرات اپی ژنتیکی از جمله متیلاسیون غیرطبیعی پروموتر ژن متیلن تتراهیدروفولات ردوکتاز (mthfr) و برخی پلی مورفیسم ها از جمله، پلی مورفیسم mthfr c677t اشاره کرد. mthfr آنزیمی است که در تنظیم متابولیسم فولات و متیونین نقش دارد. هدف از این تح...

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