In this study, Pt1Sn1 intermetallic nanoparticles (NPs) on SiO2/CeO2@SiO2 composites were located either SiO2 or CeO2@SiO2, thereby varying the average distance (intimacy) between metal sites and CeOx from “closest” to “nanoscale”. The catalytic performance of these catalysts was compared dual-bed mixtures Pt1Sn1@SiO2 CeO2@SiO2 powders, which provided a “milliscale” sites. Several beneficial ef...

The development of a practical and scalable process for the asymmetric synthesis of sitagliptin is reported. Density functional theory calculations reveal that two noncovalent interactions are responsible for the high diastereoselection. The first is an intramolecular hydrogen bond between the enamide NH and the boryl mesylate S═O, consistent with MsOH being crucial for high selectivity. The se...

an alumina supported co/ni catalyst was prepared by sol-gel procedure to study the catalytic behavior during fischer-tropsch synthesis in a fixed-bed reactor. the effect of co conversion (10-50%) on hydrocarbon product distribution (ch4, c5+ and c2-c4 olefin selectivities) was studied. selectivity for ch4 decreased, while those of c5+ and olefin selectivities increased with increasing co conver...

Despite the previous literature describing the "low-to-modest" efficiency, the readily available C5-acetamide donor was reinvestigated for its use in α-sialylation under microfluidic conditions. The N-phenyltrifluoroacetimidate donor was efficiently mixed with an appropriate amount of TMSOTf to produce the α(2-6) and α(2-3)-sialylation products of galactose and glucosamine acceptors in excellen...

A series of substituted isoquinolinones were synthesized and their binding affinities and functional activities towards human melatonin MT1 and MT2 receptors were evaluated. Structure-activity relationship analysis revealed that substituted isoquinolinones bearing a 3-methoxybenzyloxyl group at C5, C6 or C7 position respectively (C5>C6>C7 in terms of their potency) conferred effective binding a...

Mn-promoted bulk iron catalysts with a high specific surface area (82–211 m2·g−1) were synthesized by coprecipitation followed drying under supercritical conditions. The tested in the CO2 hydrogenation to valuable C2-C5 hydrocarbons. exhibited better textural properties than bare Fe2O3 catalyst, allowing dispersion of active phase, easier reduction and carburization oxides and, consequently, re...

Biological assembly processes offer inspiration for ordering building blocks across multiple length scales into advanced functional materials. Such bioinspired strategies are attractive assembling supported catalysts, where shaping and structuring essential their performance but still remain tremendously difficult to achieve. Here, we present a simple route toward catalysts with tunable activit...

Aquaporins are transmembrane channels that facilitate the permeation of water and small, uncharged amphipathic molecules across cellular membranes. One distinct aquaporin subfamily contains pure water channels, whereas a second subfamily contains channels that conduct small alditols such as glycerol, in addition to water. Distinction between these substrates is central to aquaporin function, th...

Catalytic fast pyrolysis of polyolefinic waste streams was investigated to recover valuable base chemicals at high selectivity. HZSM-5 zeolite with different properties, affected by Si/Al, mesoporosity, phosphorus stabilization, and steaming, were tested thoroughly characterized. Different feeds, catalyst/feed ratios reaction temperatures evaluated in a micropyrolysis reactor coupled two-dimens...

The preparation of a crystalline, peracetyl adamantanyl thiosialoside donor protected by an isothiocyanate group is described. On activation at -78 °C in the presence of typical carbohydrate acceptors, this donor gives high yields of the corresponding sialosides with exquisite α-selectivity. The high selectivity extends to the 4-O-benzyl-protected 3-OH acceptors, which are typically less reacti...