The incorporation in vitro of formate-C14 into normal breast tissue protein, taken from different individuals and from the same individual at different times, was rela tively consistent. Administration of estradiol did not appreciably affect the rate of in corporation of formate-C14 into proteins or protein-bound serine of normal breast tis sue. However, surviving neoplastic breast tissue showe...

The incorporation of the C14 of glutamate-2-CI4 and glutamate-5-C14 into fatty acids by epididymal fat pads and liver slices suggests the operation of the following metabolic pathway : a-ketoglutarate + isocitrate -+ cbaconitate + citrate + acetyl CoA + oxalacetate (referred to as the backward reaction of the Krebs cycle). Fatty acid-C14 recoveries from glutamate-2-C14, glutamate5-C14, and acet...

Eutectic alloys are natural in-situ composites with near-equilibrium structures, impressive strength-ductility trade-off, and perfect castability. In the current study, novel eutectic Al-Cr-Nb-Ti-Zr refractory high entropy (RHEAs) were designed using a CALPHAD (CALculation of PHAse Diagrams) approach. A starting Nb30Ti40Zr30 (at.%) alloy was based on single-phase bcc solid solution. Alloying Cr...

Amethopterin in toxic amounts, whether given in a single dose or in repeated daily doses, produced no observable inhibition of the nicotinamide-induced synthesis of diphosphopyridine nucleotide in mouse liver in vivo. Likewise, no inhibition was de tected of the incorporation of formate-C14 into the total liver acid-soluble adenine. However, administration of amethopterin sufficient to produce ...

Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strategy to fight resistant fungal isolates. Recently, amphiphilic tobramycin analogu...

We have used sedimentation equilibrium analytical ultracentrifugation to measure the free energy change for the glycophorin A transmembrane helix-helix dimerization in C14 betaine micelles. By varying the amount of micellar C14 betaine, we show that the protein association reaction in the micellar C14 phase behaves as an ideal-dilute solution. In this hydrophobic environment, the mole-fraction ...