the objective of this study was to determine the prevalence and distribution of chlamydia trachomatisgenotypes in shiraz, iran. two hundred twelve cervical swab samples were collected from women attendingshahid motahari polyclinic in shiraz, iran. the endocervical specimens were screened for c. trachomatis byplasmid pcr. genotyping was performed in c. trachomatis-positive samples by nested pcr ...

Chlamydia trachomatis is an obligate intracellular bacterium which causes a wide variety of human infections such as ocular, urogenital and respiratory infections. Genital infections of women, espe-cially when repeated, give rise to many complications such as ectopic pregnancy, miscarriage and in‌fertility. Since chlamydial infections are usually asymptomatic, they progress unnoticed and produc...

Background: Chlamydia (C.) trachomatis is an obligate intracellular gram-negative pathogen affecting over 600 million people worldwide with 92 million new cases occurring globally each year. Genital C. trachomatis infection has been recognized as the most common cause of pelvic inflammatory disease leading to severe tubal damage, ectopic pregnancy, hydrosalpinx and infertility. However, the mec...

chlamydia trachomatis is the most common agent of urogenital infections in both men and women. diagnosis of chlamydial infections is based on isolation of bacteria in tissue culture media that requires at least 48 to 72h. polymerase chain reaction (pcr) is a sensitive and specific method for detection of small quantity of bacterial dna in clinical samples. the first goal of this study was to pe...

objective: the objective of this research was to determine the prevalence of genital c. trachomatis infection in asymptomatic women by using highly sensitive nested-polymerase chain reaction (pcr) in urine sample. materials and methods: one hundred-forty asymptomatic women were randomly selected from those who attended gynecology out patient department of hazraat e rasool hospital in tehran. fi...

BackgroundGenetic systems have been developed forChlamydiabut the extremely low transformation frequency remains a significant bottleneck. Our goal is to develop self-replicating transposon delivery vector forC. trachomatiswhich can be expanded prior transposase induction.<ns4:bo...

Female BALB/c mice were immunized intranasally with the mouse pneumonitis biovar of Chlamydia trachomatis and subsequently challenged in the ovarian bursa (C. trachomatis immunized, C. trachomatis challenged). Two groups of mice served as controls. One group was sham immunized intranasally with mock-infected HeLa 229 cell extracts and was challenged in the ovarian bursa with C. trachomatis MoPn...

Repeat Chlamydia trachomatis detection frequently occurs within months after C. trachomatis infection treatment. The origins of such infection (persistence versus reinfection from untreated or new partners) are varied and difficult to determine. C. trachomatis strains can be differentiated by sequencing the ompA gene encoding the outer membrane protein A (OmpA). We used OmpA genotyping to inves...

Chlamydia trachomatis is a global human pathogen causing diseases ranging from blinding trachoma to pelvic inflammatory disease. To explore how innate and adaptive immune responses cooperate to protect against systemic infection with C. trachomatis L2, we investigated the role of macrophages (Mphi) and dendritic cells (DCs) in the stimulation of C. trachomatis-specific CD8(+) T cells. We found ...