Background Endometriosis is a common gynecological disease characterized by the presence of endometrial tissue outside the uterine cavity. This disease affects approximately 10% of women in reproductive age and is associated with pelvic pain, dysmenorrhea and infertility. The theory of involvement of stem cells is a considered new hypothesis in etiology of endometriosis.The aim of this study wa...

Objective(s): Gestational diabetes increases the risk of congenital heart disease in the offspring, but the molecular mechanism underlying this process remains unclear. Therefore, the current study was conducted to assess the effects of induced gestational diabetes on expression of some involved genes in cardiac hypertrophy in the offspring of diabetic rats.Materials and Methods: Diabetes was i...

Introduction Background: Considering the poorly understood mechanism of lysine demethylase 1A (KDM1A) in osteosarcoma (OS), we here commence our investigation to fill blank. Material and methods Methods: Following transfection as appropriate, 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) flow cytometry assays were used determine viability apoptosis OS cells MG-63, which ge...

Uncontrolled proliferation and apoptosis evasion are two hallmarks of acute myeloid leukemia (AML), but the molecular mechanisms remain poorly understood. In this study, it is demonstrated that double over-expresser oncoprotein c-Myc anti-apoptotic protein Bcl-2 a critical “genetic overdrive” in AML associated with poor genetic alterations. Double-knockdown c-Myc/ synergistically kills cells vi...

Abstract High-risk medulloblastomas are tumours with a poor survival prognosis (≤ 50%), which currently treated radiation therapy and DNA-damaging chemotherapy. The severe side effects of these treatments, including developmental problems secondary tumours, underscore the need for new treatments reduced toxicity. An attractive target such is Myc-family proteins since high-risk amplify either N-...

AIM. The aim of the study was to analyze Avra's effector in inducing cancer stem cells into colon through increased radical oxygen species (ROS), PTEN expression and c-myC as markers tumorigenesis mice model colorectal infected with S. typhimurium.
 METHODS. used balb c induced once a week by 10 mg / mL day AOM for 1-week 12-week treatment period. Isolation typhimurium specific protein had...