background : historically, leishmanization is the most effective protective measure against cutaneous leishmaniasis (cl), cl lesion induced by leishmanization sometimes takes a long time to heal. ma­nipulation of leishmanization inoculums needed to induce a mild and acceptable cl lesion. the aim of this study was to explore if liposomal form of cpg odn (cytosin phosphate guanin oligodeoxynu­cle...

Adriamycin (ADR)-induced nephropathy is frequently utilized in rodent models of podocytopathy. However, the application this model mice limited to a few strains, such as BALB/c mice. The most commonly used mouse strain, C57BL/6 (B6), resistant ADR-induced nephropathy, are all strains with B6 genetic background. Reportedly, R2140C variant Prkdc gene cause susceptibility To verify hypothesis, we ...

objective(s) quinazolinones are heterocyclic components (able to form cyclized compounds) which have several medical effects such as anti-malarial, spasmolytic, anti-microbial, sedative, etc. they are also known for their fungicidal properties, inhibition of tyrosine-kinase and dna repair enzyme poly (adp-ribose) polymerase (parp) and are also effective in treatment of cancer, diabetes, and par...

background: to evaluate the immunological properties of leishmania major excreted- secreted (e-s) products on the progress of leishmaniasis in susceptible balb/c mice. methods: promastigotes of the leishmania major were cultured and e-s products were collected during the culture preiod. groups of balb/c mice (n= 12) were immunized with e-s products or whole antigen. animals were challenged with...

for the first time, a spectrum of morphological abnormalities have been produced in developingmouse embryos (n=50), by injecting (ip) 75 and 100 mg/kg of maternal body weight of a new quinazolinonederivative, 4(3h)quinazolinone-2-propyl-2-phenylethyl(qppe), on days 9, 10 and 11 of gestation.measurements of the length of the crown-rump (cr), weight of body of the embryos and placenta on day 17sh...

objective: cryptosporidiosis is a parasitic disease that is causing small protozoan genus cryptosporidum and transmission take place through fecal- oral by direct contact or indirectly through food or drink. the aim of this study was detection of anti-cryptosporidum parvum immunoglobulin igg, in newborn balb/c infected with c. parvum. materials and methods: oocysts of c. parvum were obtained f...