The tricho-rhino-phalan-geal syndrome is characterized by sparse fine hair, bulbous nose, and brachydac-tyly. The clinical and radiological findings of four affected family members, a father and his three children, are presented. Cardiovascular anomalies, previously unreported in this syndrome,were present in one of the children. Psychological and immunological evaluations were found to be esse...

INTRODUCTION Crooked or deviated nose is a deviation of the nose from the straight vertical position of the face. Extensive pneumatization of the middle turbinate, also called concha bullosa or bullous middle turbinate (BMT) is known to be one of the possible etiologic factors in nasal obstruction, recurrent sinusitis, and headache. There is no study concerning a link between BMT and crooked no...

Schimke immuno-osseous dysplasia is a rare autosomal recessive disorder that affects primarily bone, T lymphocytes, kidneys, and skin. The patients have a triangular face, broad nasal bridge, bulbous nose tip, small palpebral fissures, short neck, long upper lip, and low hairline. Dental abnormalities of affected patients have not been discussed in detail. The patient described in this clinical...

Tricho-rhino-phalangeal syndrome type I (TRPS I) is characterized by a bulbous nose, sparse hair and epiphyseal coning. Autosomal dominant and recessive transmission are suggested. The presence of cone-shaped epiphyses, the major complaint of patients due to swelling over the phalangeal joints, requires differential diagnosis among various syndromes. This paper, describing a ten-year-old girl w...

Rhinoplasty is one of the most common aesthetic procedures in the world. It is the most common aesthetic surgery procedure in Iran. Achieving complete patient satisfaction is almost impossible but improving the aesthetics and function of the nose is the aim of surgery. This report describes a 34 years old woman with a large bump in the tip of the nose after three times cosmetic rhinoplasties. T...

The medial Permian (~270-260 Ma: Guadalupian) was a time of important tetrapod faunal changes, in particular reflecting a turnover from pelycosaurian- to therapsid-grade synapsids. Until now, most knowledge on tetrapod distribution during the medial Permian has come from fossils found in the South African Karoo and the Russian Platform, whereas other areas of Pangaea are still poorly known. We ...

Rhinophyma is the most prevalent presentation of the phymatous subtype of rosacea. Rosacea subtypes include erythematotelangiectatic type (type 1), papulopustular rosacea (type 2), phymatous rosacea (type 3) and ocular rosacea (type 4).[1] Phymatous rosacea is characterized early by prominent follicular pores or patulous follicles with mild swelling while advanced disease reveals pronounced hyp...

Trichorhinophalangeal syndrome types I and III (TRPS1, OMIM 190350; TRPS3, OMIM 190351) are rare hereditary diseases with autosomal dominant inheritance (1, 2). The first case was reported in 1966 (3). In 2000 the TRPS1 gene was identified as one of its causative genes and mapped to chromosomal region 8q24.1 (1). These syndromes have characteristic sparse and slow-growing hair, craniofacial abn...

A family is reported in which the 'acromegaloid facial appearance' (AFA) phenotype was segregating through two generations. The five affected persons showed a striking resemblance to the patients previously reported, including progressively coarse acromegaloid-like facial appearance, narrow palpebral fissures, bulbous nose, and thickening of the lips and intraoral mucosa, resulting in exaggerat...

Whether bulbous, Roman, or pug, the nose gets all the credit. But the actual star of smell is an unassuming patch of tissue, several centimeters square, tucked up inside each nasal cavity. After a whiff of a peach or a lilac, this tissue captures the volatile chemicals traveling into each nostril. The chemicals bind to receptors on the tissue's millions of neurons, the neurons relay the informa...