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More than half of patients receiving prescription medicine for cancer pain have been reported to experience inadequate pain relief or breakthrough pain. Buccal administration can deliver lipophilic opioids rapidly to the systemic circulation through the buccal mucosa, limiting gastrointestinal motility and first-pass metabolism. This review updates the safety and efficacy of fentanyl buccal sol...

Buccal delivery of saquinavir has the advantage to bypass hepatic first-pass metabolism associated with oral administration. Local microenvironmental pH (pHM) modification at buccal mucosa might increase absorption by balancing solubility and partition into mucosa. The present study aimed evaluate a novel pHM modifying film using effervescence, as well elucidate relationship between permeation ...

ABSTRACT
 In 2020 the number of cases Dengue Hemorrhagic Fever in Indonesia until 49th week reached 95,893 and caused death around 661 people. This study aims to obtain bestformula buccal film by optimizing concentration HPMC K15M Na. CMC evaluation characterization ofpreparations with 3 variations ratios against formulas on Na polymer excipients. include F1 0.67% : 0.33% ; F2 0.65% 0.5% F...

The bioadhesive buccal film drug delivery technology that increases the safety, effectiveness, and stability of active pharmaceutical ingredients is main focus current article. cutting-edge since it offers a better way to maximise treatment effectiveness. medications are used increase bioavailability have high first-pass metabolism ideal for this strategy. Rolling, hot-melt extrusion, solid dis...