The resorption of brushite-based bone cements has been shown to be highly unpredictable, with strong dependence on a number of conditions. One of the major factors is phase transformation, with change to more stable phases such as hydroxyapatite affecting the rate of resorption. Despite its importance, the analysis of phase transformation has been largely undertaken using methods that only dete...

Calcium phosphate cements (CPCs) are widely used in bone repair. Currently there are two main types of CPCs, brushite and apatite. The aim of this project was to evaluate the mechanical properties of particularly promising experimental brushite and apatite formulations in comparison to commercially available brushite- and apatite-based cements (chronOS(™) Inject and Norian(®) SRS(®), respective...

Brushite, CaHPO4·2H2O, is a crystalline hydrated acidic form of calcium phosphate that occurs in both physiological and pathological biomineralization processes. Additionally, it is biocompatible in humans. Several groups have investigated the experimental Fourier transform infrared vibrational spectrum of brushite. These investigations have led to a longstanding debate concerning the correct a...

Depending upon local conditions, brushite (CaHPO4 x 2 H2O) cements may be largely resorbed or (following hydrolysis to hydroxyapatite) remain stable in vivo. To determine which factors influence cement resorption, previous studies have investigated the solution-driven degradation of brushite cements in vitro in the absence of any cells. However, the mechanism of cell-mediated biodegradation of ...

We have developed a phytochrome immunoaffinity purification procedure that yields undegraded oat (Avena sativa L., cv. Garry) phytochrome of greater than 98% purity within 2 hours when starting with a brushite-purified preparation. Immunoaffinity-purified phytochrome, except for its greater purity, is indistinguishable from conventionally purified phytochrome by gel exclusion chromatography, is...

Statement of Purpose: Calcium phosphate cements are prepared by mixing calcium phosphate powder with a liquid component to form a paste that hardens over time via a dissolution-precipitation reaction. Thus, in addition to being osteoconductive and resorbable, these biomaterials have the advantageous property of being injectable. This property can be leveraged for castingbased approaches to scaf...

Ajaxon, I. 2017. Can Bone Void Fillers Carry Load? Behaviour of Calcium Phosphate Cements Under Different Loading Scenarios. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1492. 67 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9865-8. Calcium phosphate cements (CPCs) are used as bone void fillers and as complements to hardware ...

The calcic phosphates represent a complex family. Their conditions of crystallisation and inhibition were studied at various pH values. Phosphate precipitates obtained from artificial urine in the pH range (6.5; 7; 8) were identified using FTIR and XRD. At pH = 6.5 brushite accompanied by carbonated amorphous phosphate complexes precipitated while at pH = 7, the coexistence of brushite, struvit...

The effect of Ca2+ amount and sintering temperature on mechanical properties geopolymer-brushite (GPB) binders was investigated. Brushite raw abandoned kaolinite clay thermally transformed into metakaolin were used for GPB synthesis. complete phase structural analyses performed by X-ray powder diffraction, Fourier transforms infrared spectroscopy (FT-IR). pore-filling as a consequence ions inco...

The enhanced catalytic activity of permanently polarized hydroxyapatite, which is achieved using a thermally stimulated polarization process, largely depends on both the experimental conditions used to prepare crystalline hydroxyapatite from its calcium and phosphate precursors process parameters. A mineral similar brushite, an apatitic phase that can evolve found at surface highly hydroxyapati...