The antihyperlipidemic and antioxidant activities of dietary supplementation of sea tangle from Goseong and the alginate-free residue of sea tangle were investigated in Sprague Dawley rats treated with a high-fat diet, streptozotocin, poloxamer 407, and bromobenzene. The alginate-free residue of Goseong sea tangle induced a significant reduction in triglycerides and total cholesterol levels, as...

The peroxidation of polyunsaturated fatty acids present in the membrane lipids has been proposed as the mechanism by which a number of foreign compounds produce structural tissue injury [1-3]. For certain chemicals, such as bromotrichloroethane and carbon tetrachloride, it is clear that lipid peroxidation may have a critical role in bringing about the tissue damage [3-5]. However, in respect to...

Bromobenzene (BrB), a hydrophobic, recalcitrant organic compound, is listed by the environmental protection agencies as an environmental and marine pollutant having hepatotoxic, mutagenic, teratogenic, and carcinogenic effects. The tropical marine yeast Yarrowia lipolytica 3589 was seen to grow aerobically on BrB and displayed a maximum growth rate (μmax) of 0.04 h-1. Furthermore, we also obser...

Treatment of rats with phenobarbital, which stimulates the activity of the drug-metabolizing enzymes in the liver, potentiates hepatic necrosis elicited by bromobenzene and a number of other chemically inert halogenated aromatic hydrocarbons. Radioautographic studies indicate that [(14)C]bromobenzene is covalently bound at the sites of necrosis. From these results, it is inferred that the hepat...

A specific antibody was prepared against rat liver heme oxygenase which had been induced by bromobenzene treatment. Immunochemical studies with this antibody (IgG) revealed that heme oxygenases from livers of rats treated with hemin, Cd2+, Co2+, or bromobenzene from rat spleen and also from kidney of Sn2+-treated rats were all immunochemically identical. Cell-free synthesis of heme oxygenase wa...

The time course and acinar distribution of bromobenzene-induced hepatic necrosis was studied in the rat. Cellular damage, lipid infiltration, and changes in glycogen deposits were investigated by light microscopy 6, 16, 24, and 48 hr after bromobenzene (BZ) administration. Concomitantly, ultrastructural changes were followed by electron microscopy in each zone of the acinus. To insure accurate ...