Objective of the study is to screen for in vitro pharmacological activities of 5-Lipoxygenase and cytotoxicity of using methanolic callus extracts of Biophytum sensitivum. In vitro Brine shrimp lethality assay was carried out according to the method of Meyer et al., (1982) and the lipoxygenase inhibition activity was assayed using photometric method as described by Reddanna et al., (1985). The ...

OBJECTIVE To investigate the toxicity of methanol extract of various parts (Root, Stem, Leaf, Flower and Fruit) of Lantana camara (L. Camara) in Artemia salina. METHODS The methanol extracts of L. camara were tested for in vivo brine shrimp lethality assay. RESULTS All the tested extract exhibited very low toxicity on brine shrimp larva. The results showed that the root extract was the most...

This study assessed the performance of a bioluminescent bacterial assay, the ToxScreen-II Test (Photobacterium leiognathi), in comparison to the brine shrimp (Artemia franciscana) nauplii lethality assay for the detection of toxicity associated with Aloe vera leaf gel extract and the organophosphate pesticide Mevinphos. In both bioassays, clear dose-response relationships were demonstrated for ...

Cinnamomum species have long been used as spices. The preliminary bioactive constituent’s identification and brine shrimp lethality activities of ethanolic extracts of seven Cinnamomum species viz., C. travancoricum, C. walaiwarense, C. wightii, C. verum, C. sulphuratum, C. riparium, and C. perrottetii were evaluated in this study. The results of cytotoxic activity of the bark extracts of seven...

General toxicity, antiproliferative, antibacterial and antioxidant activities of Caulerpa peltata J.V.Lamouroux (Caulerpaceae) collected from Oman Sea were investigated. Dried, ground alga was Soxhlet-extracted with hexane, dichloromethane and methanol successively. The methanol extract was subjected to vacuum liquid chromatography (VLC) fractionation on silica gel using a step gradient of diff...

OBJECTIVE To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta (E. hirta) in MCF-7 cell line model using comet assay. METHODS The cytotoxicity of E. hirta extract was investigated by employing brine shrimp lethality assay and the genotoxicity of E. hirta was assessed by using Comet assay. RESULTS Both toxicity tests exhibited significant toxicity result. In the comet as...

Sesbania Grandiflora (Family: Leguminosae) is a medicinal plant used as tumor suppressant agent in Ayurveda, a traditional system of medicine practiced in sub-continental India. The aim of the study was to systematically investigate and reveal the cytotoxic potential of sesbania grandiflora bark extract [petroleum ether (BP), Chloroform (BC), Methanol extract (BM) and Aqueous extract (BA)] agai...

numerous studies have been focused on natural anticarcinogenic agents. many antioxidants have been identified as anticarcinogens. antimutagens have also been proposed as cancer chemopreventive agents. the use of natural products as anticancer has a long history that began with traditional medicine. the aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

Numerous studies have been focused on natural anticarcinogenic agents. Many antioxidants have been identified as anticarcinogens. Antimutagens have also been proposed as cancer chemopreventive agents. The use of natural products as anticancer has a long history that began with traditional medicine. The aim of this study was to evaluate cytotoxicity and antioxidant activity of twenty-three plant...

The investigation was conducted with methanolic fruit extract of Averrhoa carambola for its antibacterial and cytotoxic activities. Antibacterial activity of the extract was evaluated against various Gram-positive and Gram-negative bacteria using disk diffusion technique. For cytotoxic activity, brine shrimp lethality bioassay was performed to estimate LC50 values. In our preliminary screening,...