Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated t...

background: amplification of her2 is seen in 20-30% of breast cancer cases. measurement of her2 gene amplification appears to be of vital importance in planning the treatment schedule for patients with breast carcinoma. the aim of our study was to evaluate her2 amplification status in malignant and benign breast tumors by differential pcr (dpcr). materials and methods: the genomic dna was extra...

background: baculoviral inhibitor of apoptosis repeat-containing 5 (birc5) gene is an inhibitor of apoptosis that expresses in human embryonic tissues but it is absent in most healthy adult tissues. the copy number of birc5 has been indicated to be highly increased in tumor tissues; however, its association with the age of onset in breast cancer is not well understood. methods: forty tumor tiss...

background and objectives: breast cancer is the most common malignancy in women throughout the world. there are controversial reports on the role of human papillomavirus (hpv) infection in breast carcinogenesis. the aim of this study was to assess the presence of hpv-dna in invasive breast carcinoma to determine the association between hpv infection and breast carcinoma. methods: the study incl...

breast cancer affects iranian women at least one decade younger than their counterparts in othercountries and the incidence of breast fibroadenoma is growing in the last two decades in tehran. thisstudy aimed to compare the ahr levels in premenopausal breast cancer and breast fibroadnemo withappropriate normal groups. possible associations of ahr with lifestyle and reproductive risk factorsand ...

Background and Objectives: Breast cancer is the most common malignancy in women throughout the world. There are controversial reports on the role of human papillomavirus (HPV) infection in breast carcinogenesis. The aim of this study was to assess the presence of HPV-DNA in invasive breast carcinoma to determine the association between HPV infection and breast carcinoma. Methods: The study inc...

background: breast cancer is the most common malignancy in females worldwide. several etiological factors including environmental factors have been recognized for breast cancer. epstein barr virus as a viral etiological factor has been proposed. so far, several studies have investigated the relationship between development of breast cancer and epstein barr virus, but few have been done in iran....

background: ultrasound propagation velocity was measured experimentally in normal, fibroadenoma and ductal carcinoma breast tissues, in order to distinguish normal breast tissue from tumors. materials and methods: in quantitative measurements of ultrasound velocity, 403 breast tissue images were selected, comprising 130 normal breast tissue, 130 fibroadenoma, and 143 ductal carcinoma tumors. th...

the mitochondrial dna (mtdna) mutations in mitochondrial coding and non coding regions seem to be important in carcinogenesis. the aim of this investigation was to evaluate coding region (mt-trnaphe and trnapro) and non-coding sequence, mitochondrial displacement loop (mtdna d-loop), in the cancerous and non-cancerous lesions of iranian patients with breast cancer (bc). genomic dna was extracte...