Abstract It is widely accepted by physicists and philosophers of physics alike that there are certain contexts in which general relativity will “break down”. In such cases, one expects to need some as-yet undiscovered successor theory. This paper discuss pathologies might be taken signal the theory breaking down, consider how expect a do better. The upshot an unconventional interpretation “Stro...

We present a single server in which customers arrive in batches and the server provides service one by one. The server provides two heterogeneous service stages such that service time of both stages is different and mandatory to all arriving customers in such a way that, after the completion of first stage, the second stage should also be provided to the customers. The server may subject to ran...

hen yeast secretory proteins are improperly folded, the ER quality control system directs them into the HRD/DER pathway, which targets the proteins for degradation. Blocking the HRD/DER pathway, however, does not completely stop degradation, implying that there must be an alternative way to destroy misfolded secretory proteins. Haynes et al., reporting on page 91, have now characterized that pa...

The Government has taken a further step towards devolving responsibility for industrial relations policy to local health authorities. New guidelines on handling industrial disputes published by the DHSS express the Government's determination to stand well back from these and not interfere: "Ministers want NHS management to know that, having issued this guidance, they would hope not to intervene...