BACKGROUND Cognitive deficits are common in multiple sclerosis (MS) and require continuous monitoring. In routine examinations, screening instruments such as the Brief Repeatable Battery (BRB) may serve this purpose. It was suggested that even a shortened version of the BRB, comprising the Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT) and Selective Reminding T...

BACKGROUND Black raspberries (BRB) inhibit a broad range of cancers in preclinical models, including in vivo models of oral, esophageal, colon, breast and skin cancer. Promising preclinical results have led to clinical evaluations in cancer patients or patients at increased risk for cancer development. OBJECTIVE To summarize clinical investigations targeting cancer or precancerous lesions wit...

Buckling-restrained brace (BRB) is a dual-function device that improves the seismic resistance and energy-dissipation capacity of structures in earthquake engineering. To achieve expected performance under severe ground motions, BRB usually designed to remain elastic mild earthquakes, leading increased forces insignificant vibration-reduction effect on at this stage. This study extends concept ...

Abstract This paper examines the optimal placement, numbers, and shape of Buckling Restrained Braces (BRB) for a 3D shear-wall frame building structure based on linear static analysis utilizing ETABS software. The total amount BRBs referred to as number are considered design variables objective function be minimized is maximum story displacement inter-story drift. diagonal (D), X-shape (X), V-s...

Black raspberries (BRB) demonstrate potent inhibition of aerodigestive tract carcinogenesis in animal models. However, translational clinical trials evaluating the ability of BRB phytochemicals to impact molecular biomarkers in the oral mucosa remain limited. The present phase 0 study addresses a fundamental question for oral cancer food-based prevention: Do BRB phytochemicals successfully reac...

PURPOSE To test the hypothesis that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides a useful in vivo measure of passive blood retinal barrier permeability surface area product (BRB PS) in experimental diabetic retinopathy. METHODS BRB PS (cm(3)/min) was measured using DCE-MRI and Gd-DTPA (MW 590 Da) in urethane-anesthetized control rats, sodium iodate-treated rats, rat...

To address the issue of rule premise combination explosion in construction traditional complete conjunctive belief base (BRB), this paper introduces an orthogonal design method to reduce BRB. The reasoning based on reduced BRB is designed with help conversion technology from disjunctive Finally, operational mission effectiveness evaluation taken as example verify proposed method. results show t...

The shear walls are essential seismic elements to increase buildings bearing capacity against earthquakes. In mid- and high-rise buildings, subjected predominant bending deformation under earthquakes, the responses in upper floors increase. order utilize appropriately, previous studies proposed install until a certain building level, referred as curtailed wall. However, frame structure without ...

PURPOSE Azurocidin, released by neutrophils during leukocyte-endothelial interaction, is a main cause of neutrophil-evoked vascular leakage. Its role in the retina, however, is unknown. METHODS Brown Norway rats received intravitreal injections of azurocidin and vehicle control. Blood-retinal barrier (BRB) breakdown was quantified using the Evans blue (EB) dye technique 1, 3, and 24 hours aft...

PURPOSE To determine whether long-term brimonidine (BRI) treatment prevents the hyperglycemia-induced increase in vitreoretinal vascular endothelial growth factor (VEGF) expression and breakdown of the blood-retinal barrier (BRB) in streptozotocin (STZ)-induced diabetic rats. METHODS Brown Norway/Long-Evans rats were divided into three groups with similar distributions of blood glucose and bo...