OBJECTIVE Segmented brain white matter hyperintensities were compared between subjects with late-life depression and age-matched subjects with similar vascular risk factor scores. Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white and gray matter volumes were also examined. METHOD Eighty-three subjects with late-life depressio...

Introduction: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS), affecting mostly young people at a mean age of 30 years. Magnetic resonance imaging (MRI) is one of the most specific and sensitive methods in diagnosing and detecting the evolution of multiple sclerosis disease. But it does not have the ability to differentiate between distinct histopathologic...

In a patient with features indicating the presence of pseudotumor cerebri, a negative cranial CT-scan is not adequate to rule out less benign pathology and an MRI of brain should be performed. In this study, a 10-year old boy with daily headaches for one month and diplopia for one week was found to have a partial abducens palsy and bilateral papilledema; otherwise, his examination was normal. A...

PURPOSE We evaluated the impact of premature extrauterine life on brain maturation. PATIENTS AND METHODS Twelve neonates underwent MR imaging at 40 (39.64 +/- 0.98) weeks (full term). Fifteen premature infants underwent 2 MR imaging examinations, after birth (preterm at birth) and at 40 weeks (41.03 +/- 1.33) (preterm at term). A 3D MR imaging technique was used to measure brain volumes compa...

Although the study of higher brain function has traditionally focused on the cortical gray matter, recent years have witnessed the recognition that white matter also makes an important contribution to cognition and emotion. White matter comprises nearly half the brain volume and plays a key role in development, aging, and many neurologic and psychiatric disorders across the life span. More than...

In a patient with features indicating the presence of pseudotumor cerebri, a negative cranial CT-scan is not adequate to rule out less benign pathology and an MRI of brain should be performed. In this study, a 10-year old boy with daily headaches for one month and diplopia for one week was found to have a partial abducens palsy and bilateral papilledema; otherwise, his examination was normal. A...

The brain white matter is responsible for the transmission of electrical signals through the central nervous system. Lesions in the brain white matter, called white matter hyperintensity (WMH), can cause a significant functional deficit. WMH are commonly seen in normal aging, but also in a number of neurological and psychiatric disorders. We propose here an automatic method for WHM analysis in ...

PURPOSE To examine the brain damage of solvent abusers in Japan, where pure industrial toluene is frequently abused. METHODS Twenty solvent abusers 17 to 33 years of age with 7.2 +/- 4.0 years of abuse were examined with a 1.5-T MR imaging system. RESULTS White matter hyperintensities in cerebrum, brain stem, and cerebellum on T2-weighted images were found in seven cases. The extent of whit...

Sphingolipids, glycosylphosphatidylinositol (GPI)-anchored proteins, and certain signaling molecules segregate from bulk membrane lipids into lateral domains termed lipid rafts, which are often isolated based on their insolubility in cold nonionic detergents. During immunohistological studies of gangliosides, major sphingolipids of the brain, we found that cold Triton X-100 solubility is bidire...