Objective(s): Brain edema is one of the most serious causes of death within the first few days after trauma brain injury (TBI). In this study we have investigated the role of Shilajit on brain edema, blood-brain barrier (BBB) permeability, intracranial pressure (ICP) and neurologic outcomes following brain trauma.   Materials and Methods: Diffuse traumatic brain trauma was indu...

Carotid artery thrombosis and concomitant brain infarction after blunt trauma are rare conditions. We report a 34-year-old woman with multiple traumas due to pedestrian car accident. At the time of initial visiting, she was somnolent and her Glasgow coma scale (GCS) score was 14. Initial vital signs (V/S) and brain computed tomography (CT) scan were normal. One day after admission to the emerge...

there are only a few, non-evidence based, neuroprotective strategies for treatment and prevention of brain injuries after closed head trauma. to establish new therapy strategies, a novel animal model is needed. the aim of our investigation was to link standardized small animal models and actual patient medical care. data of experimental small animal studies often cannot be transferred to cns in...

traumatic brain injury is a leading cause of death in developed countries. it is estimated that only in the united states about 100,000 people die annually in parallel among the survivors there is a significant number of people with disabilities with significant costs for the health system. it has been determined that after moderate and severe traumatic injury, brain parenchyma is affected by m...

traumatic brain injury is a common entity. however cerebral infarction in infants is a rare entity while the diagnosis of this pathology in the pediatric population is usually difficult. the mild head trauma is rarely accompanied by intracranial injury and even less, with cerebral infarction. we herein report the first case of cerebral infarction after a mild brain trauma in a 2-year-old latin-...

the patient with head trauma is a challenge for the emergency physician and for the neurosurgeon. currently traumatic brain injury constitutes a public health problem. knowledge of the various supportive therapeutic strategies in the pre-hospital and pre-operative stages is essential for optimal care. the immediate rapid infusion of large volumes of crystalloids to restore blood volume and bloo...

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results loss of consciousness (gcs drop or amnesia) was markedly associated with abnormal brain ct scan (p < 0.05). interestingly, we found 7 patients with normal clinical examination but significant abnormal brain ct scan. conclusions according to the results of our study, we recommend that all patients with minor head trauma underwent brain ct scan in order not to miss any life-threatening he...

Objective: One of the most frequent causes of death and acquired disability in the pediatric population is the Traumatic Brain Injury (TBI). TBI is secondary to falls, road traffic and vehicle collisions, child abuse and assaults. Penetrating brain injury is a severe form of traumatic brain injury. Blunt head injury is more frequent than TBI in children, but the second one carries a poor progno...

luteolin, as a natural polyphenolic compound, has neuroprotective effect and exerts its function by attenuation of apoptosis and oxidative stress factors. emerging evidences indicate that oxidative stress leads to neurodegeneration but is not the initial event and endoplasmic reticulum stress (er) is often considered to be the stimulus event which is caused by accumulating of misfolded proteins...