speech delay with an unknown cause is a problem among children. this diagnosis is the last differential diagnosis after observing normal findings in routine hearing tests. the present study was undertaken to determine whether auditory brainstem responses to click stimuli are different between normally developing children and children suffering from delayed speech with unknown causes. in this cr...

introduction: brain injury is an important cause of morbidity and mortality worldwide and so far, there has been no absolute treatment for the damaged brain tissue. using human stem cells with self-assembling scaffolds can be a promising method for treatment of traumatic brain injury. materials and methods: human meningioma stem cells were isolated, cultured and then expanded into in vitro cond...

traumatic brain injury (tbi) is described as a situation in which the brain is damaged by an external force. it is considered to be a chief problem in health care. pharmacotherapy and stem cell therapy are the main treatments used in tbi. the purpose of these procedures is to control the inflammation in injured regions of brain. currently, there is no effective care for tbi that could regenerat...

Traumatic brain injury (TBI) is a disruption in the brain functions following a head trauma. Cell therapy may provide a promising treatment for TBI. Human neural stem cells cultured in self-assembling peptide scaffolds have been proposed as a potential novel method for cell replacement treatment after TBI. In the present study, we accessed the effects of human neural stem/progenitor cells (hNS/...

 Primary and secondary malignant central nervous system (CNS) tumors are devastating invasive tumors able to give rise to many kinds of differentiated tumor cells. Glioblastoma multiform (GBM), is the most malignant brain tumor, in which its growth and persistence depend on cancer stem cells with enhanced DNA damage repair program that also induces recurrence and resists current chemo- and radi...

background: amniotic membrane derived stem cells (amscs) have considerable advantages to use in regenerative medicine and their anti- inflammatory effects, growth factor secretion and differentiation potential make them suitable candidates for stem cell therapy of nervous system. the developing and neonatal brain contains a spectrum of growth factors to direct development of endogenous and dono...

background hearing capability plays a principal role on human's communication. noise-induced hearing loss (nihl) caused by exposure to high noise levels is a serious socio-economic problem in modern societies. nihl can either be reversible, resulting in a temporary threshold shifts (tts) or irreversible, resulting in a permanent threshold shifts (pts). pts is often confirmed in the time span of...

objective(s): in order to grow cells in a three-dimensional (3d) microenvironment, self-assembling peptides, such as puramatrix, have emerged with potential to mimic the extracellular matrix. the aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...

traumatic brain injury (tbi) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. the use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of tbi. in the present study, we surveyed the beneficial effec...