Objective(s): Prevention of inflammation in early stages will be useful in maintaining vitality of the organism. The objective of this study was to evaluate the effects of doxycycline (DOX) or meloxicam (MLX) monotherapy and combination therapy on the levels of inflammatory mediators in the brain tissues of rats with Escherichia coli lipopolysaccharide (LPS)-induced br...

Objective(s): Cerebral ischemia/reperfusion (I/R) causes brain inflammation that ultimately causes long time brain function disturbances. We aimed to evaluate the effect of ellagic acid (EA) on anxiety, depression, locomotion behaviors, blood-brain barrier (BBB) permeability, brain edema, and inflammation in male rats with cerebral I/R. Materials and ...

Uptake transporters in brain microvascular endothelial cells (BMECs) are involved the penetration of basic (cationic) drugs such as diphenhydramine (DPHM) into brain. Lipopolysaccharide (LPS)-induced inflammation alters expression levels and activities uptake transporters, which change DPHM A microdialysis study showed that unbound brain-to-plasma partition coefficient ( K p,uu,brain ) for LPS ...

multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. many studies have shown that inflammation causing neuronal demyelination. ms is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. platelet activating fact...

Multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. Many studies have shown that inflammation causing neuronal demyelination. MS is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. Platelet activating fact...

epilepsy is a disorder categorized by recurrent seizures and leads to changes in neuronal death and neurogenesis. recently the search for new targets in the therapy of epilepsy has focused on brain inflammation because brain inflammation and the associate blood brain barrier damage appears to be basic part of epilepsy pathophysiology-erythropoietin (epo) regulates biological processes counting ...