Neurotrophins play a protective role during cerebral ischemia, and mice lacking both alleles for neurotrophin 4 (Nt4-/- ) or deficient in a single allele for brain-derived neurotrophic factor (Bdnf+/-) have increased susceptibility to cerebral ischemia. This study directly compared the biologic activities of brain-derived neurotrophic factor (BDNF) and NT4 by replacing the coding sequence with ...

objective(s): exposing to stress may be associated with increased production of reactive oxygen species (ros). therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. it has been presented that brain-derived neurotrophic factor (bdnf) supports neurons against various neurodegenerative conditio...

S Refereed Dixon K.J. and Sherrard R.M. Brain-derived neurotrophic factor induces olivocerebellar plasticity in the mature cerebellum (2006) Federation of European Neurosciences Dixon K.J. and Sherrard R.M. Brain-derived neurotrophic factor induces olivocerebellar plasticity in the mature cerebellum (2006) Australian Neuroscience Society Dixon K.J. and Sherrard R.M. Brain-derived neurotrophic f...

Depression is a complex psychiatric disorder that significantly impacts millions of individuals worldwide. Despite advances in our understanding its neurobiological underpinnings, treatment options remain limited, and not all patients respond adequately to available therapies. Emerging evidence has implicated brain-derived neurotrophic factor (BDNF), critical regulator neuronal plasticity, the ...

Objective(s): Exposing to stress may be associated with increased production of reactive oxygen species (ROS). Therefore, high level of oxidative stress may eventually give rise to accumulation of oxidative damage and development of numerous neurodegenerative diseases. It has been presented that brain-derived neurotrophic factor (BDNF) supports neurons against various neurodegenerative conditio...

background exposure to morphine decreases neurogenesis in the hippocampus. recent studies have shown that voluntary running decreases the severity of anxiety behaviors and cognitive deficits, and increased synaptic plasticity in morphine-dependent rats. objectives this study aimed to investigate whether the morphine dependence-induced attenuation of hippocampal neuron number in rats would be re...

post-traumatic stress disorder (ptsd) is a syndrome causing from a severe traumatic happening that leads to threatened death or injury. ptsd is associated with changes in limbic, hippocampal, and prefrontal cortical region function due to changes in synaptogenesis, dendritic modifying, and neurogenesis. changes in neuron in ptsd patients result from pathophysiological disturbances in inflammato...

Background: It has been known that Brain-Derived Neurotrophic Factor (BDNF) is involved in neural survival and long term memory (LTM). Here we hypothesized that BDNF as a potent neurotrophic factor might modulate amnestic effect induced by morphine. Objectives: The aim of this study was to examine whether infusion of exogenous BDNF in the CA1 regions of the dorsal hippocampi could ameliorate me...

Background Cryopreservation of ovarian cortex is increasingly used to preserve fertility before cancer therapy. Recently, studies show that Brain-derived neurotrophic factor (BDNF) may be involved in oocyte maturation. Brain-derived neurotrophic factor (BDNF) is member of neurotrophin family that has anti-apoptotic effects on nervous system. Recent researches show that it also plays key role in...

Brain-derived neurotrophic factor (BDNF) supports hippocampal, cortical and basal forebrain cholinergic neurons, which lose function in Alzheimer's disease. In Alzheimer's tissues such as hippocampus and parietal cortex, brain- derived neurotrophic factor mRNA is decreased three- to four-fold compared with controls. However, the molecular mechanism of the down-regulation of BDNF in Alzheimer's ...